Sympathetic discharge and vascular resistance after bed rest

J. Kevin Shoemaker, Cynthia S. Hogeman, Urs A. Leuenberger, Michael D. Herr, Kristen Gray, David H. Silber, Lawrence I. Sinoway

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The effect of -6°head-down-tilt bed rest (HDBR) for 14 days on supine sympathetic discharge and cardiovascular hemodynamics at rest was assessed. Mean arterial pressure, heart rate (n = 25), muscle sympathetic nerve activity (MSNA; n = 16) burst frequency, and forearm blood flow (n = 14) were measured, and forearm vascular resistance (FVR) was calculated. Stroke distance, our index of stroke volume, was derived from measurements of aortic mean blood velocity (Doppler) and R-R interval (n = 7). With these data, an index of total peripheral resistance was determined. Heart rate at rest was greater in the post (71 ± 2 beats/min)- compared with the pre-HDBR test (66 ± 2 beats/min; P < 0.003), but mean arterial pressure was unchanged. Aortic stroke distance during post-HDBR (15.5 ± 1.1 cm/beat) was reduced from pre- HDBR levels (20.0 ± 1.5 cm/beat) (P < 0.03). Also, MSNA burst frequency was reduced in the post (16.7 ± 2.8 beats/min)- compared with the pre (25.2 ± 2.6 beats/min)-HDBR condition (P < 0.01). Bed rest did not alter forearm blood flow, FVR, or total peripheral resistance. Thus reductions in MSNA with HDBR were not associated with a decrease in FVR.

Original languageEnglish (US)
Pages (from-to)612-617
Number of pages6
JournalJournal of applied physiology
Volume84
Issue number2
StatePublished - Feb 1 1998

Fingerprint

Bed Rest
Forearm
Vascular Resistance
Arterial Pressure
Heart Rate
Stroke Volume
Hemodynamics
Muscles

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Shoemaker, J. Kevin ; Hogeman, Cynthia S. ; Leuenberger, Urs A. ; Herr, Michael D. ; Gray, Kristen ; Silber, David H. ; Sinoway, Lawrence I. / Sympathetic discharge and vascular resistance after bed rest. In: Journal of applied physiology. 1998 ; Vol. 84, No. 2. pp. 612-617.
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Sympathetic discharge and vascular resistance after bed rest. / Shoemaker, J. Kevin; Hogeman, Cynthia S.; Leuenberger, Urs A.; Herr, Michael D.; Gray, Kristen; Silber, David H.; Sinoway, Lawrence I.

In: Journal of applied physiology, Vol. 84, No. 2, 01.02.1998, p. 612-617.

Research output: Contribution to journalArticle

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AU - Shoemaker, J. Kevin

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AU - Silber, David H.

AU - Sinoway, Lawrence I.

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Shoemaker JK, Hogeman CS, Leuenberger UA, Herr MD, Gray K, Silber DH et al. Sympathetic discharge and vascular resistance after bed rest. Journal of applied physiology. 1998 Feb 1;84(2):612-617.