Sympathetic nerve responses to muscle contraction and stretch in ischemic heart failure

Satoshi Koba, Jihong Xing, Lawrence I. Sinoway, Jianhua Li

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Congestive heart failure (CHF) induces abnormal regulation of peripheral blood flow during exercise. Previous studies have suggested that a reflex from contracting muscle is disordered in this disease. However, there has been very little investigation of the muscle reflex regulating sympathetic outflows in CHF. Myocardial infarction (MI) was induced by the coronary artery ligation in rats. Echocardiography was performed to determine fractional shortening (FS), an index of the left ventricular function. We examined renal and lumbar sympathetic nerve activities (RSNA and LSNA, respectively) during 1-min repetitive (1- to 4-s stimulation to relaxation) contraction or stretch of the triceps surae muscles. During these interventions, the RSNA and LSNA responded synchronously as tension was developed. The RSNA and LSNA responses to contraction were significantly greater in MI rats (n = 13) with FS <30% than in control animals (n = 13) with FS >40% (RSNA: +49 ± 7 vs. +19 ± 4 a.u., P < 0.01; LSNA: +28 ± 7 vs. +8 ± 2 a.u., P < 0.01) at the same tension development. Stretch also increased the RSNA and LSNA to a larger degree in MI (n = 13) than in control animals (n = 13) (RSNA: +36 ± 6 vs. +19 ± 3 a.u., P < 0.05; LSNA: +24 ± 3 vs. +9 ± 2 a.u., P < 0.01). The data demonstrate that CHF exaggerates sympathetic nerve responses to muscle contraction as well as stretch. We suggest that muscle afferent-mediated sympathetic outflows contribute to the abnormal regulation of peripheral blood flow seen during exercise in CHF.

Original languageEnglish (US)
Pages (from-to)H311-H321
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume294
Issue number1
DOIs
StatePublished - Jan 1 2008

Fingerprint

Muscle Contraction
Heart Failure
Muscles
Myocardial Infarction
Reflex
Left Ventricular Function
Ligation
Echocardiography
Coronary Vessels
Kidney

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

@article{a6b2eaa5edea43aab91ba00dfd547a66,
title = "Sympathetic nerve responses to muscle contraction and stretch in ischemic heart failure",
abstract = "Congestive heart failure (CHF) induces abnormal regulation of peripheral blood flow during exercise. Previous studies have suggested that a reflex from contracting muscle is disordered in this disease. However, there has been very little investigation of the muscle reflex regulating sympathetic outflows in CHF. Myocardial infarction (MI) was induced by the coronary artery ligation in rats. Echocardiography was performed to determine fractional shortening (FS), an index of the left ventricular function. We examined renal and lumbar sympathetic nerve activities (RSNA and LSNA, respectively) during 1-min repetitive (1- to 4-s stimulation to relaxation) contraction or stretch of the triceps surae muscles. During these interventions, the RSNA and LSNA responded synchronously as tension was developed. The RSNA and LSNA responses to contraction were significantly greater in MI rats (n = 13) with FS <30{\%} than in control animals (n = 13) with FS >40{\%} (RSNA: +49 ± 7 vs. +19 ± 4 a.u., P < 0.01; LSNA: +28 ± 7 vs. +8 ± 2 a.u., P < 0.01) at the same tension development. Stretch also increased the RSNA and LSNA to a larger degree in MI (n = 13) than in control animals (n = 13) (RSNA: +36 ± 6 vs. +19 ± 3 a.u., P < 0.05; LSNA: +24 ± 3 vs. +9 ± 2 a.u., P < 0.01). The data demonstrate that CHF exaggerates sympathetic nerve responses to muscle contraction as well as stretch. We suggest that muscle afferent-mediated sympathetic outflows contribute to the abnormal regulation of peripheral blood flow seen during exercise in CHF.",
author = "Satoshi Koba and Jihong Xing and Sinoway, {Lawrence I.} and Jianhua Li",
year = "2008",
month = "1",
day = "1",
doi = "10.1152/ajpheart.00835.2007",
language = "English (US)",
volume = "294",
pages = "H311--H321",
journal = "American Journal of Physiology",
issn = "0363-6135",
publisher = "American Physiological Society",
number = "1",

}

Sympathetic nerve responses to muscle contraction and stretch in ischemic heart failure. / Koba, Satoshi; Xing, Jihong; Sinoway, Lawrence I.; Li, Jianhua.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 294, No. 1, 01.01.2008, p. H311-H321.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sympathetic nerve responses to muscle contraction and stretch in ischemic heart failure

AU - Koba, Satoshi

AU - Xing, Jihong

AU - Sinoway, Lawrence I.

AU - Li, Jianhua

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Congestive heart failure (CHF) induces abnormal regulation of peripheral blood flow during exercise. Previous studies have suggested that a reflex from contracting muscle is disordered in this disease. However, there has been very little investigation of the muscle reflex regulating sympathetic outflows in CHF. Myocardial infarction (MI) was induced by the coronary artery ligation in rats. Echocardiography was performed to determine fractional shortening (FS), an index of the left ventricular function. We examined renal and lumbar sympathetic nerve activities (RSNA and LSNA, respectively) during 1-min repetitive (1- to 4-s stimulation to relaxation) contraction or stretch of the triceps surae muscles. During these interventions, the RSNA and LSNA responded synchronously as tension was developed. The RSNA and LSNA responses to contraction were significantly greater in MI rats (n = 13) with FS <30% than in control animals (n = 13) with FS >40% (RSNA: +49 ± 7 vs. +19 ± 4 a.u., P < 0.01; LSNA: +28 ± 7 vs. +8 ± 2 a.u., P < 0.01) at the same tension development. Stretch also increased the RSNA and LSNA to a larger degree in MI (n = 13) than in control animals (n = 13) (RSNA: +36 ± 6 vs. +19 ± 3 a.u., P < 0.05; LSNA: +24 ± 3 vs. +9 ± 2 a.u., P < 0.01). The data demonstrate that CHF exaggerates sympathetic nerve responses to muscle contraction as well as stretch. We suggest that muscle afferent-mediated sympathetic outflows contribute to the abnormal regulation of peripheral blood flow seen during exercise in CHF.

AB - Congestive heart failure (CHF) induces abnormal regulation of peripheral blood flow during exercise. Previous studies have suggested that a reflex from contracting muscle is disordered in this disease. However, there has been very little investigation of the muscle reflex regulating sympathetic outflows in CHF. Myocardial infarction (MI) was induced by the coronary artery ligation in rats. Echocardiography was performed to determine fractional shortening (FS), an index of the left ventricular function. We examined renal and lumbar sympathetic nerve activities (RSNA and LSNA, respectively) during 1-min repetitive (1- to 4-s stimulation to relaxation) contraction or stretch of the triceps surae muscles. During these interventions, the RSNA and LSNA responded synchronously as tension was developed. The RSNA and LSNA responses to contraction were significantly greater in MI rats (n = 13) with FS <30% than in control animals (n = 13) with FS >40% (RSNA: +49 ± 7 vs. +19 ± 4 a.u., P < 0.01; LSNA: +28 ± 7 vs. +8 ± 2 a.u., P < 0.01) at the same tension development. Stretch also increased the RSNA and LSNA to a larger degree in MI (n = 13) than in control animals (n = 13) (RSNA: +36 ± 6 vs. +19 ± 3 a.u., P < 0.05; LSNA: +24 ± 3 vs. +9 ± 2 a.u., P < 0.01). The data demonstrate that CHF exaggerates sympathetic nerve responses to muscle contraction as well as stretch. We suggest that muscle afferent-mediated sympathetic outflows contribute to the abnormal regulation of peripheral blood flow seen during exercise in CHF.

UR - http://www.scopus.com/inward/record.url?scp=38149077952&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38149077952&partnerID=8YFLogxK

U2 - 10.1152/ajpheart.00835.2007

DO - 10.1152/ajpheart.00835.2007

M3 - Article

C2 - 17965282

AN - SCOPUS:38149077952

VL - 294

SP - H311-H321

JO - American Journal of Physiology

JF - American Journal of Physiology

SN - 0363-6135

IS - 1

ER -