Symptomatic manganese neurotoxicity in a patient with chronic liver disease

Correlation of clinical symptoms with MRI findings

Todd F. Barron, Attila G. Devenyi, Alexander Mamourian

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Hyperintense symmetric pallidal lesions have been described in chronic hepatic failure. Similar lesions are reported in experimental models of manganese neurotoxicity. We describe an 8-year-old girl with chronic hepatic failure and dystonia in association with an elevated whole blood manganese level and symmetric hyperintense pallidal lesions on magnetic resonance imaging. After hepatic transplantation, her symptoms and signs resolved with normalization of magnetic resonance imaging and the whole blood manganese suggesting that in chronic hepatic failure, the pallidal lesions may be secondary to manganese deposition.

Original languageEnglish (US)
Pages (from-to)145-148
Number of pages4
JournalPediatric Neurology
Volume10
Issue number2
DOIs
StatePublished - Jan 1 1994

Fingerprint

Manganese
Liver Diseases
Liver Failure
Chronic Disease
Magnetic Resonance Imaging
Dystonia
Liver Transplantation
Signs and Symptoms
Theoretical Models

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

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Symptomatic manganese neurotoxicity in a patient with chronic liver disease : Correlation of clinical symptoms with MRI findings. / Barron, Todd F.; Devenyi, Attila G.; Mamourian, Alexander.

In: Pediatric Neurology, Vol. 10, No. 2, 01.01.1994, p. 145-148.

Research output: Contribution to journalArticle

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