Symptoms of anxiety and depression during pregnancy and their association with low birth weight in Chinese women: a nested case control study

Shaoping Yang, Rong Yang, Shengwen Liang, Jing Wang, Nancy L. Weaver, Ke Hu, Ronghua Hu, Edwin Trevathan, Zhen Huang, Yiming Zhang, Ting Yin, Jen Jen Chang, Jinzhu zhao, Longjiao Shen, Guanghui Dong, Tongzhang Zheng, Shunqing Xu, Zhengmin Qian, Bin Zhang

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

This study is a nested case control study from a population-based cohort study conducted in Wuhan, China. The aim is to estimate the association between symptoms of depression during pregnancy (DDP), anxiety during pregnancy(ADP), and depression with anxiety during pregnancy (DADP) and low birth weight (LBW) and to examine the extent to which preterm birth (PTB) moderates these associations. Logistic regression analyses were used to model associations between DDP, ADP, and DADP and LBW. Models were stratified by the presence or absence of PTB to examine moderating effects. From the cohort study, 2853 had a LBW baby (cases); 5457 pregnant women served as controls. Women with DDP or ADP only were not at higher risk of having a LBW baby, but DADP was associated with increased risk of LBW (crude OR 1.41, 95% CI 1.17–1.70; adjusted OR 1.29, 95% CI 1.07–1.57), and the significant association was particularly evident between DADP and LBW in PTB, but not in full-term births. Our data suggests that DADP is related to an increased risk of LBW and that this association is most present in PTBs.

Original languageEnglish (US)
Pages (from-to)283-290
Number of pages8
JournalArchives of Women's Mental Health
Volume20
Issue number2
DOIs
StatePublished - Apr 1 2017

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology
  • Psychiatry and Mental health

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