Synchronization and desynchronization in epilepsy: Controversies and hypotheses

Premysl Jiruska, Marco de Curtis, John G.R. Jefferys, Catherine A. Schevon, Steven J. Schiff, Kaspar Schindler

Research output: Contribution to journalReview article

187 Citations (Scopus)

Abstract

Epilepsy has been historically seen as a functional brain disorder associated with excessive synchronization of large neuronal populations leading to a hypersynchronous state. Recent evidence showed that epileptiform phenomena, particularly seizures, result from complex interactions between neuronal networks characterized by heterogeneity of neuronal firing and dynamical evolution of synchronization. Desynchronization is often observed preceding seizures or during their early stages; in contrast, high levels of synchronization observed towards the end of seizures may facilitate termination. In this review we discuss cellular and network mechanisms responsible for such complex changes in synchronization. Recent work has identified cell-type-specific inhibitory and excitatory interactions, the dichotomy between neuronal firing and the non-local measurement of local field potentials distant to that firing, and the reflection of the neuronal dark matter problem in non-firing neurons active in seizures. These recent advances have challenged long-established views and are leading to a more rigorous and realistic understanding of the pathophysiology of epilepsy.

Original languageEnglish (US)
Pages (from-to)787-797
Number of pages11
JournalJournal of Physiology
Volume591
Issue number4
DOIs
StatePublished - Feb 1 2013

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Epilepsy
Seizures
Brain Diseases
Neurons
Population

All Science Journal Classification (ASJC) codes

  • Physiology

Cite this

Jiruska, P., de Curtis, M., Jefferys, J. G. R., Schevon, C. A., Schiff, S. J., & Schindler, K. (2013). Synchronization and desynchronization in epilepsy: Controversies and hypotheses. Journal of Physiology, 591(4), 787-797. https://doi.org/10.1113/jphysiol.2012.239590
Jiruska, Premysl ; de Curtis, Marco ; Jefferys, John G.R. ; Schevon, Catherine A. ; Schiff, Steven J. ; Schindler, Kaspar. / Synchronization and desynchronization in epilepsy : Controversies and hypotheses. In: Journal of Physiology. 2013 ; Vol. 591, No. 4. pp. 787-797.
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Jiruska, P, de Curtis, M, Jefferys, JGR, Schevon, CA, Schiff, SJ & Schindler, K 2013, 'Synchronization and desynchronization in epilepsy: Controversies and hypotheses', Journal of Physiology, vol. 591, no. 4, pp. 787-797. https://doi.org/10.1113/jphysiol.2012.239590

Synchronization and desynchronization in epilepsy : Controversies and hypotheses. / Jiruska, Premysl; de Curtis, Marco; Jefferys, John G.R.; Schevon, Catherine A.; Schiff, Steven J.; Schindler, Kaspar.

In: Journal of Physiology, Vol. 591, No. 4, 01.02.2013, p. 787-797.

Research output: Contribution to journalReview article

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