Synchronization of MEL cell commitment with cordycepin

Robert Levenson, Joseph Kernen, David Housman

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

The response of differentiating MEL cells to the nucleotide analogue cordycepin reveals a previously unrecognized aspect of the molecular events which cause commitment of these cells to terminal erythroid differentiation. Cordycepin rapidly inhibits commitment of DMSO-treated MEL cells in a dose range which does not cause cytotoxicity. Reversal of cordycepin treatment in the presence of inducer leads to a rapid and synchronous commitment of a significant proportion of cells in the culture. These results suggest that MEL cells can be blocked just prior to the point of commitment by cordycepin treatment.

Original languageEnglish (US)
Pages (from-to)1073-1078
Number of pages6
JournalCell
Volume18
Issue number4
DOIs
StatePublished - Dec 1979

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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