Synthes is and biological evaluation of novelspiro 6-methoxytetralin-1,30- pyrrolidine based organoselenocyanates against cadmium-induced oxidative and hepatic damage in mice

Ugir Hossain Sk, Arun K. Sharma, Sulekha Ghosh, Sudin Bhattacharya

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

A series of novel organoselenocyanate compounds (6a-d) having spiro[tetralin-1,3-pyrrolidine] moiety were synthesized. The compounds were evaluated for their inhibitory activity against cadmium-(Cd) induced toxicity in Swiss Albino mice. All the compounds (6a-d) inhibited the level of lipid peroxidation (LPO) and upregulated the activity of glutathione-S-transferase (GST),superoxide dismutase (SOD),catalase (CAT) and reduced glutathione (GSH) levels in treatment group in comparison to the untreated Cd control group. Serum transaminase activities,e.g.,alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also significantly lowered in the compound-treated mice. Elongation of the alkyl chain length bearing the selenocyanate (SeCN) active group enhanced the potency of the compounds,6d being the most active one (6d>6c>6b>6a).

Original languageEnglish (US)
Pages (from-to)3265-3273
Number of pages9
JournalEuropean Journal of Medicinal Chemistry
Volume45
Issue number8
DOIs
StatePublished - Aug 2010

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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