Synthes is and biological evaluation of novelspiro 6-methoxytetralin-1,30- pyrrolidine based organoselenocyanates against cadmium-induced oxidative and hepatic damage in mice

Ugir Hossain Sk; Arun K. Sharma; Sulekha Ghosh; Sudin Bhattacharya

doi:10.1016/j.ejmech.2010.04.001

Synthes is and biological evaluation of novelspiro 6-methoxytetralin-1,30- pyrrolidine based organoselenocyanates against cadmium-induced oxidative and hepatic damage in mice

Ugir Hossain Sk, Arun K. Sharma, Sulekha Ghosh, Sudin Bhattacharya

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

A series of novel organoselenocyanate compounds (6a-d) having spiro[tetralin-1,3-pyrrolidine] moiety were synthesized. The compounds were evaluated for their inhibitory activity against cadmium-(Cd) induced toxicity in Swiss Albino mice. All the compounds (6a-d) inhibited the level of lipid peroxidation (LPO) and upregulated the activity of glutathione-S-transferase (GST),superoxide dismutase (SOD),catalase (CAT) and reduced glutathione (GSH) levels in treatment group in comparison to the untreated Cd control group. Serum transaminase activities,e.g.,alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also significantly lowered in the compound-treated mice. Elongation of the alkyl chain length bearing the selenocyanate (SeCN) active group enhanced the potency of the compounds,6d being the most active one (6d>6c>6b>6a).

Original language	English (US)
Pages (from-to)	3265-3273
Number of pages	9
Journal	European Journal of Medicinal Chemistry
Volume	45
Issue number	8
DOIs	https://doi.org/10.1016/j.ejmech.2010.04.001
State	Published - Aug 2010

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery
Organic Chemistry

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10.1016/j.ejmech.2010.04.001

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title = "Synthes is and biological evaluation of novelspiro 6-methoxytetralin-1,30- pyrrolidine based organoselenocyanates against cadmium-induced oxidative and hepatic damage in mice",

abstract = "A series of novel organoselenocyanate compounds (6a-d) having spiro[tetralin-1,3-pyrrolidine] moiety were synthesized. The compounds were evaluated for their inhibitory activity against cadmium-(Cd) induced toxicity in Swiss Albino mice. All the compounds (6a-d) inhibited the level of lipid peroxidation (LPO) and upregulated the activity of glutathione-S-transferase (GST),superoxide dismutase (SOD),catalase (CAT) and reduced glutathione (GSH) levels in treatment group in comparison to the untreated Cd control group. Serum transaminase activities,e.g.,alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also significantly lowered in the compound-treated mice. Elongation of the alkyl chain length bearing the selenocyanate (SeCN) active group enhanced the potency of the compounds,6d being the most active one (6d>6c>6b>6a).",

author = "{Hossain Sk}, Ugir and Sharma, {Arun K.} and Sulekha Ghosh and Sudin Bhattacharya",

note = "Funding Information: This work is supported by grant from CSIR (I (1728)/02/EMR-II) & (9/30(032)/2003-EMR-I). Dr. Sk. gratefully acknowledges CSIR for Junior & Senior Research Fellowship. The authors wish to thank the Director, CNCI for the support in this study. We also thank Dr. Sukta Das for her helpful comments in the preparation of the manuscript.",

year = "2010",

month = aug,

doi = "10.1016/j.ejmech.2010.04.001",

language = "English (US)",

volume = "45",

pages = "3265--3273",

journal = "CHIM.THER.",

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publisher = "Elsevier Masson SAS",

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}

Synthes is and biological evaluation of novelspiro 6-methoxytetralin-1,30- pyrrolidine based organoselenocyanates against cadmium-induced oxidative and hepatic damage in mice. / Hossain Sk, Ugir; Sharma, Arun K.; Ghosh, Sulekha et al.

In: European Journal of Medicinal Chemistry, Vol. 45, No. 8, 08.2010, p. 3265-3273.

Research output: Contribution to journal › Article › peer-review

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AU - Sharma, Arun K.

AU - Ghosh, Sulekha

AU - Bhattacharya, Sudin

N1 - Funding Information: This work is supported by grant from CSIR (I (1728)/02/EMR-II) & (9/30(032)/2003-EMR-I). Dr. Sk. gratefully acknowledges CSIR for Junior & Senior Research Fellowship. The authors wish to thank the Director, CNCI for the support in this study. We also thank Dr. Sukta Das for her helpful comments in the preparation of the manuscript.

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N2 - A series of novel organoselenocyanate compounds (6a-d) having spiro[tetralin-1,3-pyrrolidine] moiety were synthesized. The compounds were evaluated for their inhibitory activity against cadmium-(Cd) induced toxicity in Swiss Albino mice. All the compounds (6a-d) inhibited the level of lipid peroxidation (LPO) and upregulated the activity of glutathione-S-transferase (GST),superoxide dismutase (SOD),catalase (CAT) and reduced glutathione (GSH) levels in treatment group in comparison to the untreated Cd control group. Serum transaminase activities,e.g.,alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also significantly lowered in the compound-treated mice. Elongation of the alkyl chain length bearing the selenocyanate (SeCN) active group enhanced the potency of the compounds,6d being the most active one (6d>6c>6b>6a).

AB - A series of novel organoselenocyanate compounds (6a-d) having spiro[tetralin-1,3-pyrrolidine] moiety were synthesized. The compounds were evaluated for their inhibitory activity against cadmium-(Cd) induced toxicity in Swiss Albino mice. All the compounds (6a-d) inhibited the level of lipid peroxidation (LPO) and upregulated the activity of glutathione-S-transferase (GST),superoxide dismutase (SOD),catalase (CAT) and reduced glutathione (GSH) levels in treatment group in comparison to the untreated Cd control group. Serum transaminase activities,e.g.,alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also significantly lowered in the compound-treated mice. Elongation of the alkyl chain length bearing the selenocyanate (SeCN) active group enhanced the potency of the compounds,6d being the most active one (6d>6c>6b>6a).

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Synthes is and biological evaluation of novelspiro 6-methoxytetralin-1,30- pyrrolidine based organoselenocyanates against cadmium-induced oxidative and hepatic damage in mice

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