Syntheses and structure-activity relationship studies of N-substituted-β-d-glucosaminides as selective cytotoxic agents

Bo Wang, Yang Liu, Yanshi Wang, Xin Liu, Mao Sheng Cheng

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Twenty-four diosgenyl saponins bearing cinnamoyl, carbamido and thiosemicarbazone groups were synthesized concisely. The cytotoxicities of the synthetic compounds on six human caner cell lines were evaluated employing MTT method. Structure-activity relationship could be observed, and two of the synthesized compounds (5c and 5f) exhibited selective inhibition on HeLa and MCF-7 cells, while three of them (5d, 5f and 5h) showed strong inhibition against HT1080.

Original languageEnglish (US)
Pages (from-to)7110-7113
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume22
Issue number23
DOIs
StatePublished - Dec 1 2012

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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