Syntheses of Nitrogen-Containing Heterocycles via Palladium-Catalyzed Intramolecular Dehydrogenative C-H Amination

William A. Nack, Gong Chen

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

This article traces the development of catalytic, intramolecular dehydrogenative C-H amination (IDCA) reactions. Over the last 10 years, effective syntheses of carbazoles, indolines and oxindoles via palladium-catalyzed sp2 intramolecular dehydrogenative C-H amination reactions have been realized. While the corresponding amination reactions of sp3 C-H bonds are more challenging, syntheses of pyrrolidines, azetidines, β-lactams and even aziridines via this manifold have been reported. 1 Introduction 2 Intramolecular Aminations of C(sp2)-H Bonds 3 Intramolecular Aminations of C(sp3)-H Bonds 4 Conclusion

Original languageEnglish (US)
Article numberst-2015-a0399-a
Pages (from-to)2505-2511
Number of pages7
JournalSynlett
Volume26
Issue number18
DOIs
StatePublished - Jun 16 2015

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Amination
Palladium
Nitrogen
Azetidines
Carbazoles
Pyrrolidines
Aziridines
Lactams

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

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abstract = "This article traces the development of catalytic, intramolecular dehydrogenative C-H amination (IDCA) reactions. Over the last 10 years, effective syntheses of carbazoles, indolines and oxindoles via palladium-catalyzed sp2 intramolecular dehydrogenative C-H amination reactions have been realized. While the corresponding amination reactions of sp3 C-H bonds are more challenging, syntheses of pyrrolidines, azetidines, β-lactams and even aziridines via this manifold have been reported. 1 Introduction 2 Intramolecular Aminations of C(sp2)-H Bonds 3 Intramolecular Aminations of C(sp3)-H Bonds 4 Conclusion",
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Syntheses of Nitrogen-Containing Heterocycles via Palladium-Catalyzed Intramolecular Dehydrogenative C-H Amination. / Nack, William A.; Chen, Gong.

In: Synlett, Vol. 26, No. 18, st-2015-a0399-a, 16.06.2015, p. 2505-2511.

Research output: Contribution to journalArticle

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