We have synthesized various coumestan derivatives from 4-hydroxy-2H-benzo[h]chromen-2-one 2. Oxidative cyclization of 4-hydroxy-2H-benzo[h]chromen-2-one with catechol and pyrogallol in presence of sodium acetate and potassium iodate gave 8, 9-dihydroxy-6H-benzo[h]benzofuro[3,2-c]chromen-6-one 3 and 8, 9, 10-trihydroxy-6H-benzo[h]benzofuro[3,2-c]chromen-6-one 4 respectively. These coumestan derivatives and 4-hydroxy-2Hbenzo[h]chromen-2-one were condensed with dimethyl sulphate and different mono and/or di alkyl halides in presence of base like anhydrous K2CO3 and dry acetone gave corresponding condensed or cyclized coumestan 6a-d, 7a-d and 4-hydroxy-2H-benzo[h]chromen-2-one 5a-b derivatives.
|Original language||English (US)|
|Number of pages||7|
|Journal||Der Pharma Chemica|
|State||Published - Dec 1 2013|
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