Synthesis and anticancer activity of 4-hydroxy naphtho coumarin derivatives and naphtho coumestans

Shubhangi S. Soman, Jigar N. Soni, Gajanan S. Inamdar, Gavin P. Robertson

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

We have synthesized various coumestan derivatives from 4-hydroxy-2H-benzo[h]chromen-2-one 2. Oxidative cyclization of 4-hydroxy-2H-benzo[h]chromen-2-one with catechol and pyrogallol in presence of sodium acetate and potassium iodate gave 8, 9-dihydroxy-6H-benzo[h]benzofuro[3,2-c]chromen-6-one 3 and 8, 9, 10-trihydroxy-6H-benzo[h]benzofuro[3,2-c]chromen-6-one 4 respectively. These coumestan derivatives and 4-hydroxy-2Hbenzo[h]chromen-2-one were condensed with dimethyl sulphate and different mono and/or di alkyl halides in presence of base like anhydrous K2CO3 and dry acetone gave corresponding condensed or cyclized coumestan 6a-d, 7a-d and 4-hydroxy-2H-benzo[h]chromen-2-one 5a-b derivatives.

Original languageEnglish (US)
Pages (from-to)201-207
Number of pages7
JournalDer Pharma Chemica
Volume5
Issue number6
StatePublished - Dec 1 2013

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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