Synthesis and antiviral activities of 3-deaza-3-fluoroaristeromycin and its 5′ analogues

Qi Chen, Chong Liu, Gloria Komazin, Terry L. Bowlin, Stewart W. Schneller

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The naturally occurring adenine based carbocyclic nucleosides aristeromycin and neplanocin A and their 3-deaza analogues have found a prominent place in the search for diverse antiviral activity agent scaffolds because of their ability to inhibit S-adenosylhomocysteine (AdoHcy) hydrolase. Following the lead of these compounds, their 3-deaza-3-fluoroaristeromycin analogues have been synthesized and their effect on S-adenosylhomocysteine hydrolase and RNA and DNA viruses determined.

Original languageEnglish (US)
Pages (from-to)6961-6964
Number of pages4
JournalBioorganic and Medicinal Chemistry
Volume22
Issue number24
DOIs
StatePublished - Dec 15 2014

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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