Synthesis and biological activity of a fluorescent schweinfurthin analogue

Craig H. Kuder, Jeffrey Neighbors, Raymond Hohl, David F. Wiemer

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Most of the natural schweinfurthins are potent and selective inhibitors of cell growth as measured by the National Cancer Institute's 60-cell line screen. Due to the limited supply of these natural products, we have initiated a program aimed at their synthesis. To date, this effort has led to the preparation of three natural schweinfurthins and more than 40 analogues, and assays on these compounds have afforded some understanding of structure-activity relationships in this family. Further development of schweinfurthins as chemotherapeutic agents would benefit from characterization of their mechanism(s) of action. This perspective led to development of a fluorescent schweinfurthin analogue that retains the differential activity of the natural products, and yet has properties that facilitate its visualization within cells.

Original languageEnglish (US)
Pages (from-to)4718-4723
Number of pages6
JournalBioorganic and Medicinal Chemistry
Volume17
Issue number13
DOIs
StatePublished - Jul 1 2009

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Bioactivity
Biological Products
Growth Inhibitors
National Cancer Institute (U.S.)
Structure-Activity Relationship
Assays
Visualization
Cells
Cell Line

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

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Synthesis and biological activity of a fluorescent schweinfurthin analogue. / Kuder, Craig H.; Neighbors, Jeffrey; Hohl, Raymond; Wiemer, David F.

In: Bioorganic and Medicinal Chemistry, Vol. 17, No. 13, 01.07.2009, p. 4718-4723.

Research output: Contribution to journalArticle

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