Synthesis and characterization of a novel iNOS/Akt inhibitor Se,Se′-1,4-phenylenebis(1,2-ethanediyl)bisisoselenourea (PBISe)-against colon cancer

Dhimant Desai, Subba Rao V. Madhunapantula, Krishnegowda Gowdahalli, Arati Sharma, Raghavendragowda Chandagaludoreswamy, Karam El-Bayoumy, Gavin P. Robertson, Shantu Amin

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Our studies demonstrate that substitution of sulfur with selenium in known iNOS inhibitor increases the compound's potency by several folds in variety of different cancers cell lines tested. Hence, this approach may be used as a strategy to increase the efficacy of the anticancer agents.

Original languageEnglish (US)
Pages (from-to)2038-2043
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Issue number6
Publication statusPublished - Mar 15 2010


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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