Modern technologies require new biomaterials to match better with natural bone in terms of mechanical properties. Recently, forsterite (Mg 2SiO4) has been introduced as a possible bioceramics due to its good biocompatibility. It has a better bending strength and fracture toughness than those of commercially available hydroxyapatite ceramics. The aim of the present work was synthesis, characterization, and bioactivity evaluation of nanostructure forsterite powder. Furthermore, the influence of crystallinity on apatite formation ability and degradation rate was investigated. Nanostructure forsterite powder unlike micron sized forsterite showed apatite formation ability. The bioactivity, biocompatibility, and good mechanical properties of nanostructure forsterite ceramic make it a suitable candidate for tissue engineering.