Synthesis and dopaminergic properties of benzo-fused analogues of quinpirole and quinelorane

Martin K.H. Doll, David E. Nichols, Jason D. Kilts, Cassandra Prioleau, Cindy P. Lawler, Mechelle M. Lewis, Richard B. Mailman

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Abstract

In an analogy to the potent catechol dopamine D1 agonists dihydrexidine (1) and dinapsoline (2), benzo rings were fused onto the structures of the dopamine D2-selective agonists quinelorane (3) and quinpirole (4). Each of the phenyl ring-substituted derivatives had significant affinity for D2 receptors, albeit somewhat lower than the two parent compounds, 3 and 4. Compounds with N-propyl and N-allyl substituents (5b, 5c, 6c, and 6d) had higher affinity for the D2 dopamine receptor than did their corresponding secondary amines (5a and 6a). Slightly different effects on affinity of an n- propyl and an n-allyl group in the new analogues of 3 and 4 suggest that different binding orientations may be invoked at the receptor.

Original languageEnglish (US)
Pages (from-to)935-940
Number of pages6
JournalJournal of Medicinal Chemistry
Volume42
Issue number5
DOIs
Publication statusPublished - Mar 11 1999

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All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery

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