Synthesis and tumor cytotoxicity of novel N-substituted glucosamine-bearing oleanolic acid derivatives

Li Ren, Yang Liu, Guihua Yu, Yuan Gao, Xin Liu, Bo Wang, Xiaonan Deng, Maosheng Cheng

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Eleven novel triterpenoid saponins, N-substituted-β-D-glucosaminide derivatives of oleanolic acid, were designed and synthesized via a stepwise glycosylation strategy. These compounds were evaluated for in vitro cytotoxic activity against six different tumor cell lines. Most of the compounds inhibited the growth of, at least, one tumor cell line effectively at micromolar concentrations. Preliminary structure-activity relationships(SARs) indicate that acylation of the nitrogen of the glucosamine-bearing triterpenoid saponins affords the compounds that are highly cytotoxic towards specific tumor cell lines.

Original languageEnglish (US)
Pages (from-to)639-643
Number of pages5
JournalChemical Research in Chinese Universities
Volume30
Issue number4
DOIs
StatePublished - Jan 1 2014

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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