Synthesis, characterization, and biocompatibility of alternating block polyurethanes based on PLA and PEG

Tingzhen Mei, Yonghe Zhu, Tongcui Ma, Tao He, Linjing Li, Chiju Wei, Kaitian Xu

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15 Scopus citations

Abstract

A series of alternating block polyurethanes (abbreviated as PULA-alt-PEG) and random block polyurethanes (abbreviated as PULA-ran-PEG) based on poly(l-lactic acid) (PLA) and poly(ethylene glycol) (PEG) were synthesized. The differences of PULA-alt/ran-PEG chemical structure, molecular weight, distribution, thermal properties, mechanical properties and static contact angle were systematically investigated. The PULA-alt/ran-PEG polyurethanes exhibited low Tg (-47.3 ∼ -34.4°C), wide mechanical properties (stress σt: 4.6-32.6 MPa, modulus E: 11.4-323.9 MPa and strain ε: 468-1530%) and low water contact angle (35.4-51.4°). Scanning electron microscope (SEM) observation showed that PULA-alt-PEG film displays rougher and more patterned surface morphology than PULA-ran-PEG does, due to more regular structures of PULA-alt-PEG. Hydrolytic degradation shows that degradation rate of random block polyurethane series PULA-ran-PEG is higher than the alternating counterpart PULA-alt-PEG. PLA segment degradation is faster than urethane linkage and PEG segment almost does not degrade in the buffer solution. Platelet adhesion study showed that all the polyurethanes possess excellent hemocompatibility. The cell culture assay revealed that PULA-alt/ran-PEG polyurethanes were cell inert and unfavorable for the attachment of rat glial cell due to the hydrophilic characters of the materials.

Original languageEnglish (US)
Pages (from-to)3243-3254
Number of pages12
JournalJournal of Biomedical Materials Research - Part A
Volume102
Issue number9
DOIs
Publication statusPublished - Sep 2014

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All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

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