Synthesis of 1,2-benzisoxazole 2-oxides

Martin George Kociolek, Olivia Hoermann

Research output: Contribution to journalArticle

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Abstract

(Chemical Equation Presented) A series of 2-hydroxyaryl ketoximes were converted to the corresponding 1,2- benzisoxazole 2-oxides by treatment with iodobenzene diacetate (in acetic acid or methanol) or N-chlorosuccinimide in water. Both methods gave moderate to excellent yields for a variety of substituted oximes under mild conditions within short reaction times. The latter method has the advantages of an aqueous solvent and lack of halogenated organic by-products.

Original languageEnglish (US)
Pages (from-to)2632-2638
Number of pages7
JournalSynthetic Communications
Volume42
Issue number17
DOIs
Publication statusPublished - Sep 1 2012

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All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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