Synthesis of 1,2-benzisoxazole 2-oxides

Martin George Kociolek, Olivia Hoermann

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

(Chemical Equation Presented) A series of 2-hydroxyaryl ketoximes were converted to the corresponding 1,2- benzisoxazole 2-oxides by treatment with iodobenzene diacetate (in acetic acid or methanol) or N-chlorosuccinimide in water. Both methods gave moderate to excellent yields for a variety of substituted oximes under mild conditions within short reaction times. The latter method has the advantages of an aqueous solvent and lack of halogenated organic by-products.

Original languageEnglish (US)
Pages (from-to)2632-2638
Number of pages7
JournalSynthetic Communications
Volume42
Issue number17
DOIs
StatePublished - Sep 1 2012

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Oximes
Oxides
Acetic Acid
Byproducts
Methanol
Water
1,2-benzisoxazole
iodobenzene
N-chlorosuccinimide

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

Kociolek, Martin George ; Hoermann, Olivia. / Synthesis of 1,2-benzisoxazole 2-oxides. In: Synthetic Communications. 2012 ; Vol. 42, No. 17. pp. 2632-2638.
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Synthesis of 1,2-benzisoxazole 2-oxides. / Kociolek, Martin George; Hoermann, Olivia.

In: Synthetic Communications, Vol. 42, No. 17, 01.09.2012, p. 2632-2638.

Research output: Contribution to journalArticle

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