Synthesis of [4a‐13C]‐6‐methyltetrahydropterin

Robert A. Lazarus, Michael A. Sulewski, Stephen J. Benkovic

Research output: Contribution to journalArticle

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Abstract

The synthesis of [4a‐13C]‐6‐methyltetrahydropterin, a synthetic cofactor for phenylalanine hydroxylase, is described. [2‐13C]‐ethyl bromoacetate was converted in four steps to [5‐13C]‐2,4‐diamino‐6‐hydroxypyrimidine in 86% yield. The latter was nitrosated, reduced, condensed with pyruvic aldehyde, and reduced to afford pure [4a‐13C]‐6‐methyltetrahydropterin in a net overall yield of 16%.

Original languageEnglish (US)
Pages (from-to)1189-1195
Number of pages7
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume19
Issue number10
DOIs
StatePublished - Oct 1982

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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