ω-(N-Maleimido)alkanoic acid hydrazides (6a-c) with C11, C7 and C5 alkyl arms have been synthesized by novel method. The method involves the reaction between maleic anhydride and ω-aminoalkanoic acids (2) to get maleamic acids (3) which are in turn cyclized to ω-(N̄-maleimido)alkanoic acids (4) using fused sodium acetate and acetic anhydride. These maleimidoalkanoic acids are activated and then converted in situ into their N-2-t-butyloxycarbonyl hydrazides (5) from which the t-butyl-based protecting group is cleaved without damage to the maleimide molety to obtain the title compounds.
|Original language||English (US)|
|Number of pages||3|
|Journal||Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry|
|State||Published - Mar 1996|
All Science Journal Classification (ASJC) codes
- Organic Chemistry