Synthesis of labeled acrylamide and N-methylolacrylamide (NMA): 15N-acrylamide, 13C-NMA, 15N-NMA, and 13C,15N-NMA

Nicole Brown, C. E. Frazier

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Labeled derivatives of N-methylolacrylamide (NMA) including 15N-NMA, 13C-NMA, and 13C,15N-NMA were synthesized and purified. A required chemical precursor, 15N-acrylamide, was also prepared. Reported methods for synthesizing unlabeled analogs are noted, and modifications to these methods for achieving the labeled materials are specified. Monomers were examined via 1H, 13C, and 15N nuclear magnetic resonance (NMR) spectroscopy. Peak assignments and coupling constants are reported for each compound. To our knowledge, this is the first reported publication on the preparation and characterization of 13C-NMA, 15N-NMA, 13C, 15N-NMA, and 15N-acrylamide.

Original languageEnglish (US)
Pages (from-to)1031-1039
Number of pages9
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume48
Issue number14
DOIs
StatePublished - Dec 1 2005

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N-methylolacrylamide
Acrylamide
Nuclear magnetic resonance spectroscopy
Publications

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

Cite this

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title = "Synthesis of labeled acrylamide and N-methylolacrylamide (NMA): 15N-acrylamide, 13C-NMA, 15N-NMA, and 13C,15N-NMA",
abstract = "Labeled derivatives of N-methylolacrylamide (NMA) including 15N-NMA, 13C-NMA, and 13C,15N-NMA were synthesized and purified. A required chemical precursor, 15N-acrylamide, was also prepared. Reported methods for synthesizing unlabeled analogs are noted, and modifications to these methods for achieving the labeled materials are specified. Monomers were examined via 1H, 13C, and 15N nuclear magnetic resonance (NMR) spectroscopy. Peak assignments and coupling constants are reported for each compound. To our knowledge, this is the first reported publication on the preparation and characterization of 13C-NMA, 15N-NMA, 13C, 15N-NMA, and 15N-acrylamide.",
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TY - JOUR

T1 - Synthesis of labeled acrylamide and N-methylolacrylamide (NMA)

T2 - 15N-acrylamide, 13C-NMA, 15N-NMA, and 13C,15N-NMA

AU - Brown, Nicole

AU - Frazier, C. E.

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Labeled derivatives of N-methylolacrylamide (NMA) including 15N-NMA, 13C-NMA, and 13C,15N-NMA were synthesized and purified. A required chemical precursor, 15N-acrylamide, was also prepared. Reported methods for synthesizing unlabeled analogs are noted, and modifications to these methods for achieving the labeled materials are specified. Monomers were examined via 1H, 13C, and 15N nuclear magnetic resonance (NMR) spectroscopy. Peak assignments and coupling constants are reported for each compound. To our knowledge, this is the first reported publication on the preparation and characterization of 13C-NMA, 15N-NMA, 13C, 15N-NMA, and 15N-acrylamide.

AB - Labeled derivatives of N-methylolacrylamide (NMA) including 15N-NMA, 13C-NMA, and 13C,15N-NMA were synthesized and purified. A required chemical precursor, 15N-acrylamide, was also prepared. Reported methods for synthesizing unlabeled analogs are noted, and modifications to these methods for achieving the labeled materials are specified. Monomers were examined via 1H, 13C, and 15N nuclear magnetic resonance (NMR) spectroscopy. Peak assignments and coupling constants are reported for each compound. To our knowledge, this is the first reported publication on the preparation and characterization of 13C-NMA, 15N-NMA, 13C, 15N-NMA, and 15N-acrylamide.

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JF - Journal of Labelled Compounds and Radiopharmaceuticals

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