Synthesis of Platinum Derivatives of Polymeric and Cyclic Phosphazenes

Harry R. Allcock, Robert W. Allen, John P. O'Brien

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Polymeric and oligomeric, water-soluble anticancer derivatives have been synthesized by the reaction of [NP(NHCH3)2]n or [NP(NHCH3)2]4 with K2PtCl4. Two types of compounds were isolated. The first was formed in organic media in the presence of 18-crown-6 ether. The products contained a square planar platinum atom bonded to the nitrogen atoms of the phosphazene skeleton, as verified by the x-ray structure of PtCl2[N4P4(NHCH3)8]. The second type of derivative was formed in aqueous acid as the sait, [H2N4P4(NHCH3)g]2+[PtCl4]2_. The compounds showed tumor inhibitory activi-ty in initial anticancer screening tests. Related derivatives of formula PtCl2[N4P4(CH3)8] and [H2N4P4(CH3)8]2+[PtCl4]2-were formed when [NP(CH3)2]4 reacted respectively with PtCl2 in organic media or with K2PtCl4 in aqueous media.

Original languageEnglish (US)
Pages (from-to)3984-3987
Number of pages4
JournalJournal of the American Chemical Society
Volume99
Issue number12
DOIs
StatePublished - Jan 1 1977

Fingerprint

Platinum
Crown Ethers
Derivatives
Skeleton
Atoms
Nitrogen
X-Rays
Ether
Acids
Water
Tumors
Ethers
Screening
X rays
Neoplasms
platinum tetrachloride
18-crown-6

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Allcock, Harry R. ; Allen, Robert W. ; O'Brien, John P. / Synthesis of Platinum Derivatives of Polymeric and Cyclic Phosphazenes. In: Journal of the American Chemical Society. 1977 ; Vol. 99, No. 12. pp. 3984-3987.
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Synthesis of Platinum Derivatives of Polymeric and Cyclic Phosphazenes. / Allcock, Harry R.; Allen, Robert W.; O'Brien, John P.

In: Journal of the American Chemical Society, Vol. 99, No. 12, 01.01.1977, p. 3984-3987.

Research output: Contribution to journalArticle

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N2 - Polymeric and oligomeric, water-soluble anticancer derivatives have been synthesized by the reaction of [NP(NHCH3)2]n or [NP(NHCH3)2]4 with K2PtCl4. Two types of compounds were isolated. The first was formed in organic media in the presence of 18-crown-6 ether. The products contained a square planar platinum atom bonded to the nitrogen atoms of the phosphazene skeleton, as verified by the x-ray structure of PtCl2[N4P4(NHCH3)8]. The second type of derivative was formed in aqueous acid as the sait, [H2N4P4(NHCH3)g]2+[PtCl4]2_. The compounds showed tumor inhibitory activi-ty in initial anticancer screening tests. Related derivatives of formula PtCl2[N4P4(CH3)8] and [H2N4P4(CH3)8]2+[PtCl4]2-were formed when [NP(CH3)2]4 reacted respectively with PtCl2 in organic media or with K2PtCl4 in aqueous media.

AB - Polymeric and oligomeric, water-soluble anticancer derivatives have been synthesized by the reaction of [NP(NHCH3)2]n or [NP(NHCH3)2]4 with K2PtCl4. Two types of compounds were isolated. The first was formed in organic media in the presence of 18-crown-6 ether. The products contained a square planar platinum atom bonded to the nitrogen atoms of the phosphazene skeleton, as verified by the x-ray structure of PtCl2[N4P4(NHCH3)8]. The second type of derivative was formed in aqueous acid as the sait, [H2N4P4(NHCH3)g]2+[PtCl4]2_. The compounds showed tumor inhibitory activi-ty in initial anticancer screening tests. Related derivatives of formula PtCl2[N4P4(CH3)8] and [H2N4P4(CH3)8]2+[PtCl4]2-were formed when [NP(CH3)2]4 reacted respectively with PtCl2 in organic media or with K2PtCl4 in aqueous media.

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