Synthesis of poly (L-lactic acid) scaffolds under controlled freezing conditions

Harish Chinnasami, Daniel J. Hayes, Ram Devireddy

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Poly (l-lactic acid) (PLLA) scaffolds for bone grafts were prepared by using Thermally Induced Phase Separation (TIPS) method. Solutions of PLLA-dioxane was formed by dissolving a predetermined value of PLLA in dioxane (3, 7 and 10% wt/vol) at 323K. These solutions were frozen at controlled cooling rates (1, 10 and 40°C/min) in cylindrical capsules. The frozen solutions were freeze-dried for a period of 48 hours for the frozen dioxane to completely sublimate, leaving the porous PLLA scaffold. The scaffolds which were formed under different processing conditions were characterized in terms of porosity, pore sizes and compressive moduli.

Original languageEnglish (US)
Title of host publicationASME 2013 Summer Bioengineering Conference, SBC 2013
DOIs
StatePublished - Dec 1 2013
EventASME 2013 Summer Bioengineering Conference, SBC 2013 - Sunriver, OR, United States
Duration: Jun 26 2013Jun 29 2013

Publication series

NameASME 2013 Summer Bioengineering Conference, SBC 2013
Volume1 A

Other

OtherASME 2013 Summer Bioengineering Conference, SBC 2013
CountryUnited States
CitySunriver, OR
Period6/26/136/29/13

Fingerprint

Lactic acid
Scaffolds
Freezing
Lactic Acid
Mercuric Chloride
Porosity
Grafts
Phase separation
Pore size
Capsules
Bone
Cooling
Transplants
Bone and Bones
poly(lactic acid)
Processing
1,4-dioxane

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biotechnology
  • Mechanical Engineering

Cite this

Chinnasami, H., Hayes, D. J., & Devireddy, R. (2013). Synthesis of poly (L-lactic acid) scaffolds under controlled freezing conditions. In ASME 2013 Summer Bioengineering Conference, SBC 2013 (ASME 2013 Summer Bioengineering Conference, SBC 2013; Vol. 1 A). https://doi.org/10.1115/SBC2013-14168
Chinnasami, Harish ; Hayes, Daniel J. ; Devireddy, Ram. / Synthesis of poly (L-lactic acid) scaffolds under controlled freezing conditions. ASME 2013 Summer Bioengineering Conference, SBC 2013. 2013. (ASME 2013 Summer Bioengineering Conference, SBC 2013).
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Chinnasami, H, Hayes, DJ & Devireddy, R 2013, Synthesis of poly (L-lactic acid) scaffolds under controlled freezing conditions. in ASME 2013 Summer Bioengineering Conference, SBC 2013. ASME 2013 Summer Bioengineering Conference, SBC 2013, vol. 1 A, ASME 2013 Summer Bioengineering Conference, SBC 2013, Sunriver, OR, United States, 6/26/13. https://doi.org/10.1115/SBC2013-14168

Synthesis of poly (L-lactic acid) scaffolds under controlled freezing conditions. / Chinnasami, Harish; Hayes, Daniel J.; Devireddy, Ram.

ASME 2013 Summer Bioengineering Conference, SBC 2013. 2013. (ASME 2013 Summer Bioengineering Conference, SBC 2013; Vol. 1 A).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AB - Poly (l-lactic acid) (PLLA) scaffolds for bone grafts were prepared by using Thermally Induced Phase Separation (TIPS) method. Solutions of PLLA-dioxane was formed by dissolving a predetermined value of PLLA in dioxane (3, 7 and 10% wt/vol) at 323K. These solutions were frozen at controlled cooling rates (1, 10 and 40°C/min) in cylindrical capsules. The frozen solutions were freeze-dried for a period of 48 hours for the frozen dioxane to completely sublimate, leaving the porous PLLA scaffold. The scaffolds which were formed under different processing conditions were characterized in terms of porosity, pore sizes and compressive moduli.

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Chinnasami H, Hayes DJ, Devireddy R. Synthesis of poly (L-lactic acid) scaffolds under controlled freezing conditions. In ASME 2013 Summer Bioengineering Conference, SBC 2013. 2013. (ASME 2013 Summer Bioengineering Conference, SBC 2013). https://doi.org/10.1115/SBC2013-14168