Synthesis of polychlorinated biphenylenes (PCBPs): Structural characterization of 2,3,6,7-TCBP and analysis for PCBPs in human adipose tissue by negative-ion chemical ionization (NCI) mass spectrometry

E. R. Barnhart, D. G. Patterson, D. L. Ashley, C. C. Alley, J. A.H. MacBride

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

A tetrachlorobiphenylene was isolated from a SO2Cl2-biphenylene reaction mixture by reversed-phase liquid chromatography. The structural assignment of 2,3,6,7-tetrachloro-biphenylene is based on data from the synthesis route, gas chromatography/mass spectrometry, and nuclear magnetic resonance longitudinal relaxation studies. The UV photolysis of octachlorobiphenylene (OCBP) produced a mixture of tetra through octachlorobiphenylenes which provided a standard to assess the retention times of biphenylenes relative to PCDDs and PCDFs. The recoveries of the biphenylenes through the adipose tissue cleanup procedures developed for PCDDs and PCDFs ranged from 62-92%. Composite extracts from control and exposed groups were analyzed by NCI mass spectrometry and no peaks characteristic of biphenylenes were found.

Original languageEnglish (US)
Pages (from-to)2057-2062
Number of pages6
JournalChemosphere
Volume16
Issue number8-9
DOIs
StatePublished - 1987

All Science Journal Classification (ASJC) codes

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

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