Hardystonite is currently recognized as a biocompatible bio-ceramic material for a range of medical applications. In this study, pure nanocrystalline hardystonite powder was prepared by mechanochemical synthesis of zinc oxide, silicate oxide, and egg shell in a planetary ball mill followed by sintering. It was found that pure nanocrystalline hardystonite powder formation occurred following 20 h of milling and subsequent sintering at 1000 ℃ for 3 h. Hardystonite scaffold was prepared by space holder method. The results showed that 3D porous scaffolds with pore sizes in the range of 200–300 μm, total and open porosity of 81 and 76%, respectively, with compressive strength and modulus of 0.35 and 10.49 MPa, were obtained. The average crystallite size of the prepared hardystonite powder and scaffold was measured to be 28 ± 3 and 79 ± 1 nm, respectively. The bioactivity of prepared scaffold was evaluated by simulated body fluid (SBF). Considering the results obtained, it seems that, manufactured scaffolds could be a good candidate for bone tissue engineering applications.