Synthesis of the schweinfurthin hexahydroxanthene core through Shi epoxidation

Jeffrey Neighbors, Nolan R. Mente, Kelly D. Boss, Donald W. Zehnder, David F. Wiemer

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Use of a Shi epoxidation for introduction of chirality in a key epoxide intermediate, together with revised protecting group tactics, has allowed an efficient synthesis of the hexahydroxanthene subunit common to the natural schweinfurthin F and the synthetic analogue 3-deoxyschweinfurthin B.

Original languageEnglish (US)
Pages (from-to)516-519
Number of pages4
JournalTetrahedron Letters
Volume49
Issue number3
DOIs
StatePublished - Jan 14 2008

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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