Synthesis studies on the lomaiviticin A aglycone core: Development of a divergent, two-directional strategy

Ken S. Feldman, Brandon R. Selfridge

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Abstract

The enantiomer of the bicyclic lomaiviticin aglycone A core was prepared via a two-directional, divergent approach featuring (1) a double Ireland Claisen rearrangement to establish key core bonds with correct relative stereochemistry and (2) a double olefin metathesis reaction to deliver both cyclohexene rings of the target.

Original languageEnglish (US)
Pages (from-to)4499-4511
Number of pages13
JournalJournal of Organic Chemistry
Volume78
Issue number9
DOIs
Publication statusPublished - May 3 2013

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All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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