Synthetic bone: A polyphosphazene/hydroxyapatite composite

K. A. Bernheim, C. S. Reed, Harry R. Allcock

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A novel polyphosphazene/hydroxyapatite matrix was developed for use in the replacement of damaged natural bone. The calcium-chelating polymer poly[bis(carboxylatophenoxy)-phosphazene] was precipitated in solution with hydroxyapatite formed from dicalcium phosphate dihydrate and tetracalcium phosphate. This matrix demonstrated compressive strengths above 21 MPa with load cycling, while having reaction conditions at physiological pH and temperature. Microanalysis of the matrix revealed a high temperature dependence of the submicron morphology and the ability of the polymer to interconnect and nucleate hydroxyapatite particles. This matrix is a putative replacement for damaged bone due to its hardy physical properties, inoffensive solution chemistry and ability to be broken down and resorbed by the host during the formation of natural bone.

Original languageEnglish (US)
JournalJournal of Investigative Medicine
Volume47
Issue number2
StatePublished - Jan 1 1999

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Durapatite
Bone
Bone and Bones
Polymers
Composite materials
Compressive Strength
Temperature
Chelation
Osteogenesis
Compressive strength
Physical properties
Calcium
poly(phosphazene)

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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Synthetic bone : A polyphosphazene/hydroxyapatite composite. / Bernheim, K. A.; Reed, C. S.; Allcock, Harry R.

In: Journal of Investigative Medicine, Vol. 47, No. 2, 01.01.1999.

Research output: Contribution to journalArticle

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