Synthetic Nano- and Micromachines in Analytical Chemistry: Sensing, Migration, Capture, Delivery, and Separation

Wentao Duan, Wei Wang, Sambeeta Das, Vinita Yadav, Thomas E. Mallouk, Ayusman Sen

Research output: Contribution to journalReview article

72 Scopus citations


Synthetic nano- and microscale machines move autonomously in solution or drive fluid flows by converting sources of energy into mechanical work. Their sizes are comparable to analytes (sub-nano- to microscale), and they respond to signals from each other and their surroundings, leading to emergent collective behavior. These machines can potentially enable hitherto difficult analytical applications. In this article, we review the development of different classes of synthetic nano- and micromotors and pumps and indicate their possible applications in real-time in situ chemical sensing, on-demand directional transport, cargo capture and delivery, as well as analyte isolation and separation.

Original languageEnglish (US)
Pages (from-to)311-333
Number of pages23
JournalAnnual Review of Analytical Chemistry
StatePublished - Jul 22 2015


All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

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