Systemic distribution of blood flow during T-2 toxin induced shock in swine

Gregg R. Lundeen, Robert H. Poppenga, Val Richard Beasley, William B. Buck, William J. Tranquilli, Richard J. Lambert

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Systemic Distribution of Blood Flow during T-2 Toxin Induced Shock in Swine. LUNDEEN, G.R., POPPENGA, R.H., BEASLEY, V.R., BUCK, W.B., TRANQUILLI, W.J., AND LAMBERT, R.J. (1986). Fundam. Appl. Toxicol. 7, 309-323. Three groups of swine (6 per group) were used to determine hemodynamic and blood flow alterations induced by T-2 toxin. Two groups were dosed at 0.6 or 2.4 mg7sol;kg T-2 toxin, and one group served as a vehicle control (70% ethanol). Organ blood flow was determined at 0 hr (predosing) and at 90-min intervals for 6 hr postdosing using 15-μim diameter radionuclide labeled microspheres injected into the left atrium. Hemodynamic parameters were obtained at the same time points. The infusion of T-2 toxin resulted in reductions in cardiac output. This trend appeared to reverse itself in the low dose animals after 3 hr, whereas in the high dose group, cardiac output continued to decline. Mean aortic pressure (MAP) declined in a dose dependent fashion which tended to parallel the reduction observed in cardiac output. Heart rate was increased in both groups treated with T-2 toxin. Blood flow to the brain, heart, and kidneys decreased following exposure to the toxin. The relative percentage of cardiac output received by these organs, however, was maintained despite the drop in blood flow. Pancreatic and splenic blood flows were the most severely compromised as a result of T-2 toxicosis. Consequently, the percentage of cardiac output going to the pancreas and spleen was dramatically reduced. Adrenal, hepatic, and total gastrointestinal blood flows increased or did not change from control values. As a result, the percentage of cardiac output supplying these organs increased.

Original languageEnglish (US)
Pages (from-to)309-323
Number of pages15
JournalToxicological Sciences
Volume7
Issue number2
DOIs
StatePublished - Aug 1 1986

Fingerprint

T-2 Toxin
Shock
Cardiac Output
Blood
Swine
Hemodynamics
Heart Atria
Microspheres
Radioisotopes
Pancreas
Brain
Arterial Pressure
Animals
Ethanol
Spleen
Heart Rate
Kidney
Liver

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

Lundeen, G. R., Poppenga, R. H., Beasley, V. R., Buck, W. B., Tranquilli, W. J., & Lambert, R. J. (1986). Systemic distribution of blood flow during T-2 toxin induced shock in swine. Toxicological Sciences, 7(2), 309-323. https://doi.org/10.1093/toxsci/7.2.309
Lundeen, Gregg R. ; Poppenga, Robert H. ; Beasley, Val Richard ; Buck, William B. ; Tranquilli, William J. ; Lambert, Richard J. / Systemic distribution of blood flow during T-2 toxin induced shock in swine. In: Toxicological Sciences. 1986 ; Vol. 7, No. 2. pp. 309-323.
@article{06c29a4ade054feab221c6e43a295c1d,
title = "Systemic distribution of blood flow during T-2 toxin induced shock in swine",
abstract = "Systemic Distribution of Blood Flow during T-2 Toxin Induced Shock in Swine. LUNDEEN, G.R., POPPENGA, R.H., BEASLEY, V.R., BUCK, W.B., TRANQUILLI, W.J., AND LAMBERT, R.J. (1986). Fundam. Appl. Toxicol. 7, 309-323. Three groups of swine (6 per group) were used to determine hemodynamic and blood flow alterations induced by T-2 toxin. Two groups were dosed at 0.6 or 2.4 mg7sol;kg T-2 toxin, and one group served as a vehicle control (70{\%} ethanol). Organ blood flow was determined at 0 hr (predosing) and at 90-min intervals for 6 hr postdosing using 15-μim diameter radionuclide labeled microspheres injected into the left atrium. Hemodynamic parameters were obtained at the same time points. The infusion of T-2 toxin resulted in reductions in cardiac output. This trend appeared to reverse itself in the low dose animals after 3 hr, whereas in the high dose group, cardiac output continued to decline. Mean aortic pressure (MAP) declined in a dose dependent fashion which tended to parallel the reduction observed in cardiac output. Heart rate was increased in both groups treated with T-2 toxin. Blood flow to the brain, heart, and kidneys decreased following exposure to the toxin. The relative percentage of cardiac output received by these organs, however, was maintained despite the drop in blood flow. Pancreatic and splenic blood flows were the most severely compromised as a result of T-2 toxicosis. Consequently, the percentage of cardiac output going to the pancreas and spleen was dramatically reduced. Adrenal, hepatic, and total gastrointestinal blood flows increased or did not change from control values. As a result, the percentage of cardiac output supplying these organs increased.",
author = "Lundeen, {Gregg R.} and Poppenga, {Robert H.} and Beasley, {Val Richard} and Buck, {William B.} and Tranquilli, {William J.} and Lambert, {Richard J.}",
year = "1986",
month = "8",
day = "1",
doi = "10.1093/toxsci/7.2.309",
language = "English (US)",
volume = "7",
pages = "309--323",
journal = "Toxicological Sciences",
issn = "1096-6080",
publisher = "Oxford University Press",
number = "2",

}

Lundeen, GR, Poppenga, RH, Beasley, VR, Buck, WB, Tranquilli, WJ & Lambert, RJ 1986, 'Systemic distribution of blood flow during T-2 toxin induced shock in swine', Toxicological Sciences, vol. 7, no. 2, pp. 309-323. https://doi.org/10.1093/toxsci/7.2.309

Systemic distribution of blood flow during T-2 toxin induced shock in swine. / Lundeen, Gregg R.; Poppenga, Robert H.; Beasley, Val Richard; Buck, William B.; Tranquilli, William J.; Lambert, Richard J.

In: Toxicological Sciences, Vol. 7, No. 2, 01.08.1986, p. 309-323.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Systemic distribution of blood flow during T-2 toxin induced shock in swine

AU - Lundeen, Gregg R.

AU - Poppenga, Robert H.

AU - Beasley, Val Richard

AU - Buck, William B.

AU - Tranquilli, William J.

AU - Lambert, Richard J.

PY - 1986/8/1

Y1 - 1986/8/1

N2 - Systemic Distribution of Blood Flow during T-2 Toxin Induced Shock in Swine. LUNDEEN, G.R., POPPENGA, R.H., BEASLEY, V.R., BUCK, W.B., TRANQUILLI, W.J., AND LAMBERT, R.J. (1986). Fundam. Appl. Toxicol. 7, 309-323. Three groups of swine (6 per group) were used to determine hemodynamic and blood flow alterations induced by T-2 toxin. Two groups were dosed at 0.6 or 2.4 mg7sol;kg T-2 toxin, and one group served as a vehicle control (70% ethanol). Organ blood flow was determined at 0 hr (predosing) and at 90-min intervals for 6 hr postdosing using 15-μim diameter radionuclide labeled microspheres injected into the left atrium. Hemodynamic parameters were obtained at the same time points. The infusion of T-2 toxin resulted in reductions in cardiac output. This trend appeared to reverse itself in the low dose animals after 3 hr, whereas in the high dose group, cardiac output continued to decline. Mean aortic pressure (MAP) declined in a dose dependent fashion which tended to parallel the reduction observed in cardiac output. Heart rate was increased in both groups treated with T-2 toxin. Blood flow to the brain, heart, and kidneys decreased following exposure to the toxin. The relative percentage of cardiac output received by these organs, however, was maintained despite the drop in blood flow. Pancreatic and splenic blood flows were the most severely compromised as a result of T-2 toxicosis. Consequently, the percentage of cardiac output going to the pancreas and spleen was dramatically reduced. Adrenal, hepatic, and total gastrointestinal blood flows increased or did not change from control values. As a result, the percentage of cardiac output supplying these organs increased.

AB - Systemic Distribution of Blood Flow during T-2 Toxin Induced Shock in Swine. LUNDEEN, G.R., POPPENGA, R.H., BEASLEY, V.R., BUCK, W.B., TRANQUILLI, W.J., AND LAMBERT, R.J. (1986). Fundam. Appl. Toxicol. 7, 309-323. Three groups of swine (6 per group) were used to determine hemodynamic and blood flow alterations induced by T-2 toxin. Two groups were dosed at 0.6 or 2.4 mg7sol;kg T-2 toxin, and one group served as a vehicle control (70% ethanol). Organ blood flow was determined at 0 hr (predosing) and at 90-min intervals for 6 hr postdosing using 15-μim diameter radionuclide labeled microspheres injected into the left atrium. Hemodynamic parameters were obtained at the same time points. The infusion of T-2 toxin resulted in reductions in cardiac output. This trend appeared to reverse itself in the low dose animals after 3 hr, whereas in the high dose group, cardiac output continued to decline. Mean aortic pressure (MAP) declined in a dose dependent fashion which tended to parallel the reduction observed in cardiac output. Heart rate was increased in both groups treated with T-2 toxin. Blood flow to the brain, heart, and kidneys decreased following exposure to the toxin. The relative percentage of cardiac output received by these organs, however, was maintained despite the drop in blood flow. Pancreatic and splenic blood flows were the most severely compromised as a result of T-2 toxicosis. Consequently, the percentage of cardiac output going to the pancreas and spleen was dramatically reduced. Adrenal, hepatic, and total gastrointestinal blood flows increased or did not change from control values. As a result, the percentage of cardiac output supplying these organs increased.

UR - http://www.scopus.com/inward/record.url?scp=77957186281&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957186281&partnerID=8YFLogxK

U2 - 10.1093/toxsci/7.2.309

DO - 10.1093/toxsci/7.2.309

M3 - Article

VL - 7

SP - 309

EP - 323

JO - Toxicological Sciences

JF - Toxicological Sciences

SN - 1096-6080

IS - 2

ER -