Abstract

Objective: We explored effects of deep brain stimulation (DBS) in patients with Parkinson's disease (PD) on the synergic control of fingers in a multi-finger force production task and of muscles in a task involving vertical posture. Methods: The finger task involved the four fingers of a hand producing accurate total force followed by a targeted quick force pulse. The postural task involved releasing a load from extended arms. The analysis of synergies was performed within the framework of the uncontrolled manifold hypothesis. Results: DBS led to no significant changes in indices of stability during steady-state phases. In contrast, DBS improved indices of agility, quantified as anticipatory synergy adjustments that reduced stability of salient performance variables in preparation to their quick change. There were moderate-to-strong correlations between indices of both stability and agility measured in the multi-finger force production and multi-muscle whole-body action. Conclusions: Our results point at systemic changes in synergic control in PD. They show that DBS is effective in improving only one components of synergic control related to agility in performance being relatively ineffective for the stability component. Significance: The results show systemic brain mechanisms of synergies and suggest differential effects of DBS on indices of stability and agility.

Original languageEnglish (US)
Pages (from-to)1320-1332
Number of pages13
JournalClinical Neurophysiology
Volume129
Issue number6
DOIs
StatePublished - Jun 1 2018

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Deep Brain Stimulation
Fingers
Parkinson Disease
Muscles
Advisory Committees
Posture
Arm
Hand
Brain

All Science Journal Classification (ASJC) codes

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

@article{640158af8b1440188387459d4e2f4732,
title = "Systemic effects of deep brain stimulation on synergic control in Parkinson's disease",
abstract = "Objective: We explored effects of deep brain stimulation (DBS) in patients with Parkinson's disease (PD) on the synergic control of fingers in a multi-finger force production task and of muscles in a task involving vertical posture. Methods: The finger task involved the four fingers of a hand producing accurate total force followed by a targeted quick force pulse. The postural task involved releasing a load from extended arms. The analysis of synergies was performed within the framework of the uncontrolled manifold hypothesis. Results: DBS led to no significant changes in indices of stability during steady-state phases. In contrast, DBS improved indices of agility, quantified as anticipatory synergy adjustments that reduced stability of salient performance variables in preparation to their quick change. There were moderate-to-strong correlations between indices of both stability and agility measured in the multi-finger force production and multi-muscle whole-body action. Conclusions: Our results point at systemic changes in synergic control in PD. They show that DBS is effective in improving only one components of synergic control related to agility in performance being relatively ineffective for the stability component. Significance: The results show systemic brain mechanisms of synergies and suggest differential effects of DBS on indices of stability and agility.",
author = "Ali Falaki and Jo, {Hang Jin} and Mechelle Lewis and Barbara O'Connell and {De Jesus}, Sol and James McInerney and Xuemei Huang and Mark Latash",
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Systemic effects of deep brain stimulation on synergic control in Parkinson's disease. / Falaki, Ali; Jo, Hang Jin; Lewis, Mechelle; O'Connell, Barbara; De Jesus, Sol; McInerney, James; Huang, Xuemei; Latash, Mark.

In: Clinical Neurophysiology, Vol. 129, No. 6, 01.06.2018, p. 1320-1332.

Research output: Contribution to journalArticle

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AU - Latash, Mark

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