T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis

Heather Rogers, Li Wang, Xiaobing Yu, Mawadda Alnaeeli, Kairong Cui, Keji Zhao, James J. Bieker, Josef Prchal, Suming Huang, Babette Weksler, Constance Tom Noguchi

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Background: Erythropoietin is required for erythrocyte production and stimulates erythroid gene expression including EPO-R. Results: TAL1 induction promotes accessibility of EPO-R promoter to the GATA-1-TAL1-LMO2-LDB1 transcription activation complex to increase EPO-R expression. Conclusion: Forced TAL1 expression increases EPO-R and erythropoietin hypersensitivity in erythroid progenitors. Significance: Providing insight into the molecular link between TAL1 and erythropoietin activity.

Original languageEnglish (US)
Pages (from-to)36720-36731
Number of pages12
JournalJournal of Biological Chemistry
Volume287
Issue number44
DOIs
StatePublished - Oct 26 2012

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Rogers, H., Wang, L., Yu, X., Alnaeeli, M., Cui, K., Zhao, K., Bieker, J. J., Prchal, J., Huang, S., Weksler, B., & Noguchi, C. T. (2012). T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis. Journal of Biological Chemistry, 287(44), 36720-36731. https://doi.org/10.1074/jbc.M112.378398