T lineage differentiation from induced pluripotent stem cells

Fengyang Lei, Rizwanul Haque, Lauren Weiler, Kent E. Vrana, Jianxun Song

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Induced pluripotent stem (iPS) cells have potential to differentiate into T lymphocytes, however, the actual ability of iPS cells to develop into T lineages is not clear. In this study, we co-cultured iPS cells on OP9 cells expressing the Notch ligand Delta-like 1 (DL1), the iPS cells differentiated into T lymphocytes. In addition, in vitro stimulation of iPS cell-derived T lymphocytes resulted in secretion of IL-2 and IFN-γ. Moreover, adoptive transfer of iPS cell-derived T lymphocytes into Rag-deficient mice reconstituted their T cell pools. These results indicate that iPS cells are able to follow the normal program of T cell differentiation.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalCellular Immunology
Volume260
Issue number1
DOIs
StatePublished - Oct 9 2009

All Science Journal Classification (ASJC) codes

  • Immunology

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