T lymphocyte response to H-2 mutants: Cytotoxic effectors are Ly-1 +2 +

P. J. Wettstein, D. W. Bailey, L. E. Mobraaten, Jan Klein, J. A. Frelinger

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Abstract

The lymphocyte differentiation (Ly) antigen phenotype of cytotoxic effector T cells specific for H-2 mutant alloantigens was determined. Cytotoxic effectors generated in primary mixed lymphocyte culture and specific for H-2K(ba) and H-2D(da) alloantigens are sensitive to both anti-Ly-1 and anti-Ly-2 serum plus complement. Reconstitution analysis is demonstrated that the mutant-specific T cells were Ly-1 +2 +. These observations and those previously reported, which indicated that H-2K/D mutant-specific T cells proliferating in mixed lymphocyte culture were Ly-1 +2 +, demonstrated that Ly-1 +2 + T cells are immunocompetent. Furthermore, the nature of the stimulating H-2 complex alloantigen determines the Ly phenotype of response T cells.

Original languageEnglish (US)
Pages (from-to)3455-3459
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume76
Issue number7
DOIs
StatePublished - Dec 1 1979

All Science Journal Classification (ASJC) codes

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