t-Specific DNA polymorphisms among wild mice from Israel and Spain.

F. Figueroa, E. Neufeld, U. Ritte, Jan Klein

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Lehrach and his coworkers have isolated a series of DNA probes that specifically hybridize with different regions of mouse chromosome 17 within the t complex. The probes display restriction fragment length polymorphisms, RFLPs, which are specific for the t haplotypes in all laboratory mouse strains tested thus far. Some of these probes have been used to test wild mice populations for these t-associated DNA forms. It is demonstrated that populations from Germany, Switzerland, Italy, Greece, Yugoslavia, Australia, Costa Rica, and Venezuela contain chromosomes in which all the tested DNA loci display the t-specific polymorphisms. The frequency of mice carrying these chromosomes is as high as 31%. Wild mice from Israel and Spain, on the other hand, carry chromosomes displaying t-specific DNA forms only at one or two of the probed loci, while the other loci carry the wild-type (+) forms. These chromosomes thus resemble the partial t haplotypes known from the study of laboratory mice. One possible interpretation of these findings is that these DNA polymorphisms contributed to the assembly of the complete t haplotypes and that these haplotypes may have originated in the Middle East.

Original languageEnglish (US)
Pages (from-to)157-160
Number of pages4
JournalGenetics
Volume119
Issue number1
StatePublished - Jan 1 1988

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Israel
Spain
Haplotypes
DNA
Chromosomes
Restriction Fragment Length Polymorphisms
Yugoslavia
Costa Rica
Venezuela
Chromosomes, Human, Pair 17
Middle East
Greece
DNA Probes
Switzerland
Italy
Population
Germany

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Figueroa, F., Neufeld, E., Ritte, U., & Klein, J. (1988). t-Specific DNA polymorphisms among wild mice from Israel and Spain. Genetics, 119(1), 157-160.
Figueroa, F. ; Neufeld, E. ; Ritte, U. ; Klein, Jan. / t-Specific DNA polymorphisms among wild mice from Israel and Spain. In: Genetics. 1988 ; Vol. 119, No. 1. pp. 157-160.
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Figueroa, F, Neufeld, E, Ritte, U & Klein, J 1988, 't-Specific DNA polymorphisms among wild mice from Israel and Spain.', Genetics, vol. 119, no. 1, pp. 157-160.

t-Specific DNA polymorphisms among wild mice from Israel and Spain. / Figueroa, F.; Neufeld, E.; Ritte, U.; Klein, Jan.

In: Genetics, Vol. 119, No. 1, 01.01.1988, p. 157-160.

Research output: Contribution to journalArticle

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Figueroa F, Neufeld E, Ritte U, Klein J. t-Specific DNA polymorphisms among wild mice from Israel and Spain. Genetics. 1988 Jan 1;119(1):157-160.