Targeted suppression of MCT-1 attenuates the malignant phenotype through a translational mechanism

Krystyna Mazan-Mamczarz, Patrick Hagner, Bojie Dai, Sharon Corl, Zhenqui Liu, Ron B. Gartenhaus

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The MCT-1 oncogene, highly expressed in a subset of non-Hodgkin's lymphomas interacts with the cap complex through its PUA domain. MCT-1 recruits DENR, a SUI1 motif containing protein that promotes translation initiation of cancer-related mRNAs. We reasoned that a PUA-domain mutant protein would repress MCT-1 function and attenuate the malignant phenotype. Human lymphoma cell lines expressing the PUA-domain mutant protein demonstrated reduced anchorage-independent growth and increased susceptibility to apoptosis. Significantly, we identified an altered translational profile in cells expressing the mutant protein. These data further buttress the role of the MCT-1 in lymphomagenesis and support the development of novel therapeutic strategies targeting MCT-1.

Original languageEnglish (US)
Pages (from-to)474-482
Number of pages9
JournalLeukemia Research
Volume33
Issue number3
DOIs
Publication statusPublished - Mar 1 2009

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All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

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