Targeting Calcium Magnesium Silicates for Polycaprolactone/Ceramic Composite Scaffolds

Cong Chen, Pilanda Watkins-Curry, Mollie Smoak, Katie Hogan, Steve Deese, Gregory T. McCandless, Julia Y. Chan, Daniel J. Hayes

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Because the natural mechanical strength of materials is highly dependent on the crystal structure, four different silicate-derived ceramics-diopside, akermanite, monticellite, and merwinite-have been synthesized and evaluated for their potential as bone augments and grafts. This sparks our interest in the fabrication of polycaprolactone (PCL)/ceramic composites for potential use as scaffolds. Diopside, which possesses the most three-dimensional structure among the four, shows the highest mechanical strength and stable structure in physiological solution when added to polycaprolactone in high concentration. In turn, the incorporation of merwinite into composite scaffolds led to materials that had poor mechanical strength and were unstable in physiological environments when ceramic concentration reaches over 50%. Cyto-compatibility and osteogenic studies of the four ceramics revealed that each ceramic is cytocompatible and supports human adipose derived stem cells (hASCs) proliferation in stromal medium. Akermanite and monticellite exhibit better osteogenic properties than diopside and merwinite, suggesting that they might be the optimal material for fabricating bone scaffolds.

Original languageEnglish (US)
Pages (from-to)94-102
Number of pages9
JournalACS Biomaterials Science and Engineering
Volume1
Issue number2
DOIs
StatePublished - Feb 9 2015

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Magnesium Silicates
Polycaprolactone
Scaffolds
Strength of materials
Silicates
Magnesium
Calcium
Composite materials
Bone
Cell proliferation
Stem cells
Electric sparks
Grafts
Crystal structure
Fabrication
polycaprolactone
diopside

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

Cite this

Chen, Cong ; Watkins-Curry, Pilanda ; Smoak, Mollie ; Hogan, Katie ; Deese, Steve ; McCandless, Gregory T. ; Chan, Julia Y. ; Hayes, Daniel J. / Targeting Calcium Magnesium Silicates for Polycaprolactone/Ceramic Composite Scaffolds. In: ACS Biomaterials Science and Engineering. 2015 ; Vol. 1, No. 2. pp. 94-102.
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title = "Targeting Calcium Magnesium Silicates for Polycaprolactone/Ceramic Composite Scaffolds",
abstract = "Because the natural mechanical strength of materials is highly dependent on the crystal structure, four different silicate-derived ceramics-diopside, akermanite, monticellite, and merwinite-have been synthesized and evaluated for their potential as bone augments and grafts. This sparks our interest in the fabrication of polycaprolactone (PCL)/ceramic composites for potential use as scaffolds. Diopside, which possesses the most three-dimensional structure among the four, shows the highest mechanical strength and stable structure in physiological solution when added to polycaprolactone in high concentration. In turn, the incorporation of merwinite into composite scaffolds led to materials that had poor mechanical strength and were unstable in physiological environments when ceramic concentration reaches over 50{\%}. Cyto-compatibility and osteogenic studies of the four ceramics revealed that each ceramic is cytocompatible and supports human adipose derived stem cells (hASCs) proliferation in stromal medium. Akermanite and monticellite exhibit better osteogenic properties than diopside and merwinite, suggesting that they might be the optimal material for fabricating bone scaffolds.",
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Chen, C, Watkins-Curry, P, Smoak, M, Hogan, K, Deese, S, McCandless, GT, Chan, JY & Hayes, DJ 2015, 'Targeting Calcium Magnesium Silicates for Polycaprolactone/Ceramic Composite Scaffolds', ACS Biomaterials Science and Engineering, vol. 1, no. 2, pp. 94-102. https://doi.org/10.1021/ab500011x

Targeting Calcium Magnesium Silicates for Polycaprolactone/Ceramic Composite Scaffolds. / Chen, Cong; Watkins-Curry, Pilanda; Smoak, Mollie; Hogan, Katie; Deese, Steve; McCandless, Gregory T.; Chan, Julia Y.; Hayes, Daniel J.

In: ACS Biomaterials Science and Engineering, Vol. 1, No. 2, 09.02.2015, p. 94-102.

Research output: Contribution to journalArticle

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AU - Hayes, Daniel J.

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