Targeting calcium transport in ischaemic heart disease

M. A.Hassan Talukder, Jay L. Zweier, Muthu Periasamy

Research output: Contribution to journalReview articlepeer-review

80 Scopus citations

Abstract

Ischaemic heart disease (IHD) is the leading cause of morbidity and mortality worldwide. While timely reperfusion of acutely ischaemic myocardium is essential for myocardial salvage, it leads to a unique type of injury known as 'myocardial ischaemia/reperfusion (I/R) injury'. Growing evidence suggests that a defect in myocardial Ca2+ transport system with cytosolic Ca 2+ overload is a major contributor to myocardial I/R injury. Progress in molecular genetics and medicine in past years has clearly demonstrated that modulation of Ca2+ handling pathways in IHD could be cardioprotective. The potential benefits of these strategies in limiting I/R injury are vast, and the time is right for challenging in vivo systemic work both at pre-clinical and clinical levels.

Original languageEnglish (US)
Pages (from-to)345-352
Number of pages8
JournalCardiovascular Research
Volume84
Issue number3
DOIs
StatePublished - 2009

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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