Targeting hexokinase 2 in castration-resistant prostate cancer

Yibin Deng, Junxuan Lu

Research output: Contribution to journal › Comment/debate

6 Citations (Scopus)

Abstract

Aerobic glycolysis, known as the Warburg effect, is one of the hallmarks of cancer cells. We recently reported that the hexokinase 2 (HK2)-mediated Warburg effect is required for castration-resistant prostate cancer that is driven by Pten/p53 deficiency, suggesting that HK2 might be a therapeutic target for prostate cancer patients carrying PTEN and p53 mutations.

Original languageEnglish (US)
Article numbere974465
JournalMolecular and Cellular Oncology
Volume2
Issue number3
DOIs
StatePublished - Jul 3 2015

Fingerprint

Hexokinase
Castration
Prostatic Neoplasms
Glycolysis
Mutation
Neoplasms
Therapeutics

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Cancer Research

Cite this

Deng, Yibin ; Lu, Junxuan. / Targeting hexokinase 2 in castration-resistant prostate cancer. In: Molecular and Cellular Oncology. 2015 ; Vol. 2, No. 3.
@article{4ba1694d04f3498bbfc573517245b68a,
title = "Targeting hexokinase 2 in castration-resistant prostate cancer",
abstract = "Aerobic glycolysis, known as the Warburg effect, is one of the hallmarks of cancer cells. We recently reported that the hexokinase 2 (HK2)-mediated Warburg effect is required for castration-resistant prostate cancer that is driven by Pten/p53 deficiency, suggesting that HK2 might be a therapeutic target for prostate cancer patients carrying PTEN and p53 mutations.",
author = "Yibin Deng and Junxuan Lu",
year = "2015",
month = "7",
day = "3",
doi = "10.4161/23723556.2014.974465",
language = "English (US)",
volume = "2",
journal = "Molecular and Cellular Oncology",
issn = "2372-3556",
publisher = "Taylor and Francis Ltd.",
number = "3",

}

Deng, Y & Lu, J 2015, 'Targeting hexokinase 2 in castration-resistant prostate cancer', Molecular and Cellular Oncology, vol. 2, no. 3, e974465. https://doi.org/10.4161/23723556.2014.974465

Targeting hexokinase 2 in castration-resistant prostate cancer. / Deng, Yibin; Lu, Junxuan.

In: Molecular and Cellular Oncology, Vol. 2, No. 3, e974465, 03.07.2015.

Research output: Contribution to journal › Comment/debate

TY - JOUR

T1 - Targeting hexokinase 2 in castration-resistant prostate cancer

AU - Deng, Yibin

AU - Lu, Junxuan

PY - 2015/7/3

Y1 - 2015/7/3

N2 - Aerobic glycolysis, known as the Warburg effect, is one of the hallmarks of cancer cells. We recently reported that the hexokinase 2 (HK2)-mediated Warburg effect is required for castration-resistant prostate cancer that is driven by Pten/p53 deficiency, suggesting that HK2 might be a therapeutic target for prostate cancer patients carrying PTEN and p53 mutations.

AB - Aerobic glycolysis, known as the Warburg effect, is one of the hallmarks of cancer cells. We recently reported that the hexokinase 2 (HK2)-mediated Warburg effect is required for castration-resistant prostate cancer that is driven by Pten/p53 deficiency, suggesting that HK2 might be a therapeutic target for prostate cancer patients carrying PTEN and p53 mutations.

UR - http://www.scopus.com/inward/record.url?scp=85025676935&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85025676935&partnerID=8YFLogxK

U2 - 10.4161/23723556.2014.974465

DO - 10.4161/23723556.2014.974465

M3 - Comment/debate

AN - SCOPUS:85025676935

VL - 2

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

SN - 2372-3556

IS - 3

M1 - e974465

ER -

Deng Y, Lu J. Targeting hexokinase 2 in castration-resistant prostate cancer. Molecular and Cellular Oncology. 2015 Jul 3;2(3). e974465. https://doi.org/10.4161/23723556.2014.974465

Access to Document