Targeting hexokinase 2 in castration-resistant prostate cancer

Yibin Deng, Junxuan Lu

Research output: Contribution to journalComment/debate

6 Citations (Scopus)

Abstract

Aerobic glycolysis, known as the Warburg effect, is one of the hallmarks of cancer cells. We recently reported that the hexokinase 2 (HK2)-mediated Warburg effect is required for castration-resistant prostate cancer that is driven by Pten/p53 deficiency, suggesting that HK2 might be a therapeutic target for prostate cancer patients carrying PTEN and p53 mutations.

Original languageEnglish (US)
Article numbere974465
JournalMolecular and Cellular Oncology
Volume2
Issue number3
DOIs
StatePublished - Jul 3 2015

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Hexokinase
Castration
Prostatic Neoplasms
Glycolysis
Mutation
Neoplasms
Therapeutics

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Cancer Research

Cite this

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abstract = "Aerobic glycolysis, known as the Warburg effect, is one of the hallmarks of cancer cells. We recently reported that the hexokinase 2 (HK2)-mediated Warburg effect is required for castration-resistant prostate cancer that is driven by Pten/p53 deficiency, suggesting that HK2 might be a therapeutic target for prostate cancer patients carrying PTEN and p53 mutations.",
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Targeting hexokinase 2 in castration-resistant prostate cancer. / Deng, Yibin; Lu, Junxuan.

In: Molecular and Cellular Oncology, Vol. 2, No. 3, e974465, 03.07.2015.

Research output: Contribution to journalComment/debate

TY - JOUR

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AU - Lu, Junxuan

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AB - Aerobic glycolysis, known as the Warburg effect, is one of the hallmarks of cancer cells. We recently reported that the hexokinase 2 (HK2)-mediated Warburg effect is required for castration-resistant prostate cancer that is driven by Pten/p53 deficiency, suggesting that HK2 might be a therapeutic target for prostate cancer patients carrying PTEN and p53 mutations.

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