Targeting hexokinase 2 in castration-resistant prostate cancer

Yibin Deng; Junxuan Lu

doi:10.4161/23723556.2014.974465

Targeting hexokinase 2 in castration-resistant prostate cancer

Yibin Deng, Junxuan Lu

Research output: Contribution to journal › Comment/debate

9 Scopus citations

Abstract

Aerobic glycolysis, known as the Warburg effect, is one of the hallmarks of cancer cells. We recently reported that the hexokinase 2 (HK2)-mediated Warburg effect is required for castration-resistant prostate cancer that is driven by Pten/p53 deficiency, suggesting that HK2 might be a therapeutic target for prostate cancer patients carrying PTEN and p53 mutations.

Original language	English (US)
Article number	e974465
Journal	Molecular and Cellular Oncology
Volume	2
Issue number	3
DOIs	https://doi.org/10.4161/23723556.2014.974465
State	Published - Jul 3 2015

Fingerprint

All Science Journal Classification (ASJC) codes

Molecular Medicine
Cancer Research

Cite this

Deng, Y., & Lu, J. (2015). Targeting hexokinase 2 in castration-resistant prostate cancer. Molecular and Cellular Oncology, 2(3), [e974465]. https://doi.org/10.4161/23723556.2014.974465

@article{4ba1694d04f3498bbfc573517245b68a,

title = "Targeting hexokinase 2 in castration-resistant prostate cancer",

abstract = "Aerobic glycolysis, known as the Warburg effect, is one of the hallmarks of cancer cells. We recently reported that the hexokinase 2 (HK2)-mediated Warburg effect is required for castration-resistant prostate cancer that is driven by Pten/p53 deficiency, suggesting that HK2 might be a therapeutic target for prostate cancer patients carrying PTEN and p53 mutations.",

author = "Yibin Deng and Junxuan Lu",

year = "2015",

month = jul

day = "3",

doi = "10.4161/23723556.2014.974465",

language = "English (US)",

volume = "2",

journal = "Molecular and Cellular Oncology",

issn = "2372-3556",

publisher = "Taylor and Francis Ltd.",

number = "3",

}

TY - JOUR

T1 - Targeting hexokinase 2 in castration-resistant prostate cancer

AU - Deng, Yibin

AU - Lu, Junxuan

PY - 2015/7/3

Y1 - 2015/7/3

N2 - Aerobic glycolysis, known as the Warburg effect, is one of the hallmarks of cancer cells. We recently reported that the hexokinase 2 (HK2)-mediated Warburg effect is required for castration-resistant prostate cancer that is driven by Pten/p53 deficiency, suggesting that HK2 might be a therapeutic target for prostate cancer patients carrying PTEN and p53 mutations.

AB - Aerobic glycolysis, known as the Warburg effect, is one of the hallmarks of cancer cells. We recently reported that the hexokinase 2 (HK2)-mediated Warburg effect is required for castration-resistant prostate cancer that is driven by Pten/p53 deficiency, suggesting that HK2 might be a therapeutic target for prostate cancer patients carrying PTEN and p53 mutations.

UR - http://www.scopus.com/inward/record.url?scp=85025676935&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85025676935&partnerID=8YFLogxK

U2 - 10.4161/23723556.2014.974465

DO - 10.4161/23723556.2014.974465

M3 - Comment/debate

AN - SCOPUS:85025676935

VL - 2

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

SN - 2372-3556

IS - 3

M1 - e974465

ER -

Access to Document

10.4161/23723556.2014.974465