TY - JOUR
T1 - Targeting hexokinase 2 in castration-resistant prostate cancer
AU - Deng, Yibin
AU - Lu, Junxuan
PY - 2015/7/3
Y1 - 2015/7/3
N2 - Aerobic glycolysis, known as the Warburg effect, is one of the hallmarks of cancer cells. We recently reported that the hexokinase 2 (HK2)-mediated Warburg effect is required for castration-resistant prostate cancer that is driven by Pten/p53 deficiency, suggesting that HK2 might be a therapeutic target for prostate cancer patients carrying PTEN and p53 mutations.
AB - Aerobic glycolysis, known as the Warburg effect, is one of the hallmarks of cancer cells. We recently reported that the hexokinase 2 (HK2)-mediated Warburg effect is required for castration-resistant prostate cancer that is driven by Pten/p53 deficiency, suggesting that HK2 might be a therapeutic target for prostate cancer patients carrying PTEN and p53 mutations.
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U2 - 10.4161/23723556.2014.974465
DO - 10.4161/23723556.2014.974465
M3 - Comment/debate
AN - SCOPUS:85025676935
VL - 2
JO - Molecular and Cellular Oncology
JF - Molecular and Cellular Oncology
SN - 2372-3556
IS - 3
M1 - e974465
ER -