Targeting RNA-binding proteins in acute and chronic leukemia

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

RNA-binding proteins (RBPs) play a crucial role in cellular physiology by regulating RNA processing, translation, and turnover. In neoplasms, RBP support of cancer-relevant expression of alternatively spliced, modified, and stabilized mRNA transcripts is essential to self-renewal, proliferation, and adaptation to stress. In this review, we assess the impact of key families of RBPs in leukemogenesis, review progress in targeting those proteins with small molecules, and discuss how multilevel composition of posttranscriptional regulation of gene expression could be used for potential therapies in acute and chronic leukemia.

Original languageEnglish (US)
Pages (from-to)360-376
Number of pages17
JournalLeukemia
Volume35
Issue number2
DOIs
StatePublished - Feb 2021

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Targeting RNA-binding proteins in acute and chronic leukemia'. Together they form a unique fingerprint.

Cite this