T‐cell acute lymphoblastic leukaemia with late developing Philadelphia chromosome

Barbara Miller, Michael M. Reid, Marilyn Nell, Jeffrey M. Lipton, Stephen E. Sallan, David G. Nathan, Ramana Tantravahi

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Summary A case of childhood T‐cell acute lymphoblastic leukaemia (ALL) is presented in which the only chromosome abnormality at diagnosis was a deletion of part of the short arm of one chromosome 9 (9p). Cytogenetic studies at relapse showed, in addition to 9p, a partial deletion of the long arm of one chromosome 6 (6q) and the Philadelphia chromosome (Ph1) produced as a result of the classical translocation t(9q+;22q). All metaphases from haemopoietic colonies grown from a cryopreserved specimen of this patient's marrow at relapse were normal, in contrast to haemopoietic colonies cultured from patients with chronic myelogenous leukaemia (CML) which contained the Ph1. A hypothesis which incorporates T‐cell ALL with late development of the Ph1 into the overall family of Ph1 positive diseases is suggested.

Original languageEnglish (US)
Pages (from-to)139-146
Number of pages8
JournalBritish Journal of Haematology
Volume56
Issue number1
DOIs
StatePublished - Jan 1 1984

Fingerprint

Philadelphia Chromosome
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Recurrence
Chromosomes, Human, Pair 9
Chromosomes, Human, Pair 6
Metaphase
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Cytogenetics
Chromosome Aberrations
Bone Marrow

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Miller, Barbara ; Reid, Michael M. ; Nell, Marilyn ; Lipton, Jeffrey M. ; Sallan, Stephen E. ; Nathan, David G. ; Tantravahi, Ramana. / T‐cell acute lymphoblastic leukaemia with late developing Philadelphia chromosome. In: British Journal of Haematology. 1984 ; Vol. 56, No. 1. pp. 139-146.
@article{eda1c77d9a9c40eb81b76be872470756,
title = "T‐cell acute lymphoblastic leukaemia with late developing Philadelphia chromosome",
abstract = "Summary A case of childhood T‐cell acute lymphoblastic leukaemia (ALL) is presented in which the only chromosome abnormality at diagnosis was a deletion of part of the short arm of one chromosome 9 (9p−). Cytogenetic studies at relapse showed, in addition to 9p−, a partial deletion of the long arm of one chromosome 6 (6q−) and the Philadelphia chromosome (Ph1) produced as a result of the classical translocation t(9q+;22q−). All metaphases from haemopoietic colonies grown from a cryopreserved specimen of this patient's marrow at relapse were normal, in contrast to haemopoietic colonies cultured from patients with chronic myelogenous leukaemia (CML) which contained the Ph1. A hypothesis which incorporates T‐cell ALL with late development of the Ph1 into the overall family of Ph1 positive diseases is suggested.",
author = "Barbara Miller and Reid, {Michael M.} and Marilyn Nell and Lipton, {Jeffrey M.} and Sallan, {Stephen E.} and Nathan, {David G.} and Ramana Tantravahi",
year = "1984",
month = "1",
day = "1",
doi = "10.1111/j.1365-2141.1984.tb01279.x",
language = "English (US)",
volume = "56",
pages = "139--146",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "1",

}

T‐cell acute lymphoblastic leukaemia with late developing Philadelphia chromosome. / Miller, Barbara; Reid, Michael M.; Nell, Marilyn; Lipton, Jeffrey M.; Sallan, Stephen E.; Nathan, David G.; Tantravahi, Ramana.

In: British Journal of Haematology, Vol. 56, No. 1, 01.01.1984, p. 139-146.

Research output: Contribution to journalArticle

TY - JOUR

T1 - T‐cell acute lymphoblastic leukaemia with late developing Philadelphia chromosome

AU - Miller, Barbara

AU - Reid, Michael M.

AU - Nell, Marilyn

AU - Lipton, Jeffrey M.

AU - Sallan, Stephen E.

AU - Nathan, David G.

AU - Tantravahi, Ramana

PY - 1984/1/1

Y1 - 1984/1/1

N2 - Summary A case of childhood T‐cell acute lymphoblastic leukaemia (ALL) is presented in which the only chromosome abnormality at diagnosis was a deletion of part of the short arm of one chromosome 9 (9p−). Cytogenetic studies at relapse showed, in addition to 9p−, a partial deletion of the long arm of one chromosome 6 (6q−) and the Philadelphia chromosome (Ph1) produced as a result of the classical translocation t(9q+;22q−). All metaphases from haemopoietic colonies grown from a cryopreserved specimen of this patient's marrow at relapse were normal, in contrast to haemopoietic colonies cultured from patients with chronic myelogenous leukaemia (CML) which contained the Ph1. A hypothesis which incorporates T‐cell ALL with late development of the Ph1 into the overall family of Ph1 positive diseases is suggested.

AB - Summary A case of childhood T‐cell acute lymphoblastic leukaemia (ALL) is presented in which the only chromosome abnormality at diagnosis was a deletion of part of the short arm of one chromosome 9 (9p−). Cytogenetic studies at relapse showed, in addition to 9p−, a partial deletion of the long arm of one chromosome 6 (6q−) and the Philadelphia chromosome (Ph1) produced as a result of the classical translocation t(9q+;22q−). All metaphases from haemopoietic colonies grown from a cryopreserved specimen of this patient's marrow at relapse were normal, in contrast to haemopoietic colonies cultured from patients with chronic myelogenous leukaemia (CML) which contained the Ph1. A hypothesis which incorporates T‐cell ALL with late development of the Ph1 into the overall family of Ph1 positive diseases is suggested.

UR - http://www.scopus.com/inward/record.url?scp=0021354486&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021354486&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2141.1984.tb01279.x

DO - 10.1111/j.1365-2141.1984.tb01279.x

M3 - Article

C2 - 6608369

AN - SCOPUS:0021354486

VL - 56

SP - 139

EP - 146

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 1

ER -