Summary A case of childhood T‐cell acute lymphoblastic leukaemia (ALL) is presented in which the only chromosome abnormality at diagnosis was a deletion of part of the short arm of one chromosome 9 (9p−). Cytogenetic studies at relapse showed, in addition to 9p−, a partial deletion of the long arm of one chromosome 6 (6q−) and the Philadelphia chromosome (Ph1) produced as a result of the classical translocation t(9q+;22q−). All metaphases from haemopoietic colonies grown from a cryopreserved specimen of this patient's marrow at relapse were normal, in contrast to haemopoietic colonies cultured from patients with chronic myelogenous leukaemia (CML) which contained the Ph1. A hypothesis which incorporates T‐cell ALL with late development of the Ph1 into the overall family of Ph1 positive diseases is suggested.
|Original language||English (US)|
|Number of pages||8|
|Journal||British Journal of Haematology|
|State||Published - Jan 1984|
All Science Journal Classification (ASJC) codes