Tea and cancer prevention: Molecular mechanisms and human relevance

Chung S. Yang, Joshua D. Lambert, Jihyeung Ju, Gang Lu, Shengmin Sang

Research output: Contribution to journalReview article

196 Citations (Scopus)

Abstract

Tea made from the leaves of the plant Camellia sinensis is a popular beverage. The possible cancer-preventive activity of tea and tea polyphenols has been studied extensively. This article briefly reviews studies in animal models, cell lines, and possible relevance of these studies to the prevention of human cancer. The cancer-preventive activity of tea constituents have been demonstrated in many animal models including cancer of the skin, lung, oral cavity, esophagus, stomach, liver, pancreas, small intestine, colon, bladder, prostate, and mammary gland. The major active constituents are polyphenols, of which (-)-epigallocatechin-3-gallate (EGCG) is most abundant, most active, and most studied, and caffeine. The molecular mechanisms of the cancer-preventive action, however, are just beginning to be understood. Studies in cell lines led to the proposal of many mechanisms on the action of EGCG. However, mechanisms based on studies with very high concentrations of EGCG may not be relevant to cancer prevention in vivo. The autooxidation of EGCG in cell culture may also produce activities that do not occur in many internal organs. In contrast to the cancer prevention activity demonstrated in different animal models, no such conclusion can be convincingly drawn from epidemiological studies on tea consumption and human cancers. Even though the human data are inconclusive, tea constituents may still be used for the prevention of cancer at selected organ sites if sufficient concentrations of the agent can be delivered to these organs. Some interesting examples in this area are discussed.

Original languageEnglish (US)
Pages (from-to)265-273
Number of pages9
JournalToxicology and Applied Pharmacology
Volume224
Issue number3
DOIs
StatePublished - Nov 1 2007

Fingerprint

Tea
Neoplasms
Animals
Polyphenols
Animal Models
Cells
Beverages
Camellia sinensis
Caffeine
Cell culture
Cell Line
Liver
Plant Leaves
Skin
Skin Neoplasms
Human Mammary Glands
Esophagus
Small Intestine
Mouth
Epidemiologic Studies

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology

Cite this

Yang, Chung S. ; Lambert, Joshua D. ; Ju, Jihyeung ; Lu, Gang ; Sang, Shengmin. / Tea and cancer prevention : Molecular mechanisms and human relevance. In: Toxicology and Applied Pharmacology. 2007 ; Vol. 224, No. 3. pp. 265-273.
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Tea and cancer prevention : Molecular mechanisms and human relevance. / Yang, Chung S.; Lambert, Joshua D.; Ju, Jihyeung; Lu, Gang; Sang, Shengmin.

In: Toxicology and Applied Pharmacology, Vol. 224, No. 3, 01.11.2007, p. 265-273.

Research output: Contribution to journalReview article

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