TEAD mediates YAP-dependent gene induction and growth control

Bin Zhao, Xin Ye, Jindan Yu, Li Li, Weiquan Li, Siming Li, Jianjun Yu, Jiandie D. Lin, Cun Yu Wang, Arul M. Chinnaiyan, Zhi Chun Lai, Kun Liang Guan

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Abstract

The YAP transcription coactivator has been implicated as an oncogene and is amplified in human cancers. Recent studies have established that YAP is phosphorylated and inhibited by the Hippo tumor suppressor pathway. Here we demonstrate that the TEAD family transcription factors are essential in mediating YAP-dependent gene expression. TEAD is also required for YAP-induced cell growth, oncogenic transformation, and epithelial-mesenchymal transition. CTGF is identified as a direct YAP target gene important for cell growth. Moreover, the functional relationship between YAP and TEAD is conserved in Drosophila Yki (the YAP homolog) and Scalloped (the TEAD homolog). Our study reveals TEAD as a new component in the Hippo pathway playing essential roles in mediating biological functions of YAP.

Original languageEnglish (US)
Pages (from-to)1962-1971
Number of pages10
JournalGenes and Development
Volume22
Issue number14
DOIs
StatePublished - Jul 15 2008

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All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology

Cite this

Zhao, B., Ye, X., Yu, J., Li, L., Li, W., Li, S., Yu, J., Lin, J. D., Wang, C. Y., Chinnaiyan, A. M., Lai, Z. C., & Guan, K. L. (2008). TEAD mediates YAP-dependent gene induction and growth control. Genes and Development, 22(14), 1962-1971. https://doi.org/10.1101/gad.1664408