Team-based multi-agent system for early detection of adverse drug reactions in postmarketing surveillance

Yanqing Ji, Hao Ying, John Yen, Shizhuo Zhu, R. Michael Massanari, Daniel C. Barth-Jones

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

Discovering unknown adverse drug reactions (ADRs) in postmarketing surveillance as early as possible is highly desirable. In the U.S., the Food and Drug Administration (FDA) has provided Web-based forms for spontaneous reporting of possible ADRs. Nevertheless, the process of analyzing and interpreting the reports, collecting additional relevant information, and drawing reliable conclusions requires collaboration between experts with different and complimentary skills (e.g., epidemiologists, biostatisticians, pharmacists and physicians). Multi-agent systems have been shown to be a promising approach for tackling distributed problem solving, especially when data sources and knowledge are distributed, and coordination and collaboration are required. Hence, we propose a team-based multi-agent framework for early detection of ADRs. In this framework, intelligent agents assist a team of experts based on a human decision making model called Recognition-Primed Decision (RPD). Fuzzy logic is used to determine the degree of similarity for retrieving experience in the RPD model. We describe our preliminary system design and illustrate its potential benefits for assisting FDA expert teams in early detection of previously unknown ADRs.

Original languageEnglish (US)
Title of host publicationNAFIPS 2005 - 2005 Annual Meeting of the North American Fuzzy Information Processing Society
Pages644-649
Number of pages6
Volume2005
DOIs
StatePublished - 2005
EventNAFIPS 2005 - 2005 Annual Meeting of the North American Fuzzy Information Processing Society - Detroit, MI, United States
Duration: Jun 26 2005Jun 28 2005

Other

OtherNAFIPS 2005 - 2005 Annual Meeting of the North American Fuzzy Information Processing Society
CountryUnited States
CityDetroit, MI
Period6/26/056/28/05

All Science Journal Classification (ASJC) codes

  • Computer Science(all)
  • Media Technology

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    Ji, Y., Ying, H., Yen, J., Zhu, S., Massanari, R. M., & Barth-Jones, D. C. (2005). Team-based multi-agent system for early detection of adverse drug reactions in postmarketing surveillance. In NAFIPS 2005 - 2005 Annual Meeting of the North American Fuzzy Information Processing Society (Vol. 2005, pp. 644-649). [1548613] https://doi.org/10.1109/NAFIPS.2005.1548613