Temperature elevations in implanted prostatic tumors in mice during magnetic nanoparticle hyperthermia: in vivo experimental study

Anilchandra Attaluri, Ronghui Ma, Liang Zhu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this study, we perform in vivo animal experiments on implanted prostatic tumors in mice to measure temperature elevation distribution in the tumor during magnetic nanoparticle hyperthermia. Temperature rises are induced by a commercially available ferrofluid injected to the center of the tumor, which is subject to an alternating magnetic field. Temperature mapping in the implanted prostatic tumors during the heating has illustrated the feasibility of elevating the tumor temperature higher than 50°C using only 0.1 cc ferrofluid injected in the tumor and under a relatively low magnetic field (3 kA/m). Ferrofluid infusion rates during intratumoral injection may affect nanoparticle spreading in tumors. Using a very slow infusion rate of 5 μl/min results in an average temperature elevation in tumors 27°C above the baseline temperatures of 37°C. However, the temperature elevations are barely 14°C when the infusion rate is 20 μl/min. Our results suggest a more confined nanoparticle distribution to the injection site using smaller infusion rates.

Original languageEnglish (US)
Title of host publicationASME 2011 Summer Bioengineering Conference, SBC 2011
Pages439-440
Number of pages2
EditionPARTS A AND B
DOIs
StatePublished - Dec 1 2011
EventASME 2011 Summer Bioengineering Conference, SBC 2011 - Farmington, PA, United States
Duration: Jun 22 2011Jun 25 2011

Publication series

NameASME 2011 Summer Bioengineering Conference, SBC 2011
NumberPARTS A AND B

Other

OtherASME 2011 Summer Bioengineering Conference, SBC 2011
CountryUnited States
CityFarmington, PA
Period6/22/116/25/11

Fingerprint

Tumors
Nanoparticles
Magnetic fluids
Temperature
Magnetic fields
Animals
Temperature distribution
Heating
Experiments

All Science Journal Classification (ASJC) codes

  • Bioengineering

Cite this

Attaluri, A., Ma, R., & Zhu, L. (2011). Temperature elevations in implanted prostatic tumors in mice during magnetic nanoparticle hyperthermia: in vivo experimental study. In ASME 2011 Summer Bioengineering Conference, SBC 2011 (PARTS A AND B ed., pp. 439-440). (ASME 2011 Summer Bioengineering Conference, SBC 2011; No. PARTS A AND B). https://doi.org/10.1115/SBC2011-53128
Attaluri, Anilchandra ; Ma, Ronghui ; Zhu, Liang. / Temperature elevations in implanted prostatic tumors in mice during magnetic nanoparticle hyperthermia : in vivo experimental study. ASME 2011 Summer Bioengineering Conference, SBC 2011. PARTS A AND B. ed. 2011. pp. 439-440 (ASME 2011 Summer Bioengineering Conference, SBC 2011; PARTS A AND B).
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Attaluri, A, Ma, R & Zhu, L 2011, Temperature elevations in implanted prostatic tumors in mice during magnetic nanoparticle hyperthermia: in vivo experimental study. in ASME 2011 Summer Bioengineering Conference, SBC 2011. PARTS A AND B edn, ASME 2011 Summer Bioengineering Conference, SBC 2011, no. PARTS A AND B, pp. 439-440, ASME 2011 Summer Bioengineering Conference, SBC 2011, Farmington, PA, United States, 6/22/11. https://doi.org/10.1115/SBC2011-53128

Temperature elevations in implanted prostatic tumors in mice during magnetic nanoparticle hyperthermia : in vivo experimental study. / Attaluri, Anilchandra; Ma, Ronghui; Zhu, Liang.

ASME 2011 Summer Bioengineering Conference, SBC 2011. PARTS A AND B. ed. 2011. p. 439-440 (ASME 2011 Summer Bioengineering Conference, SBC 2011; No. PARTS A AND B).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Attaluri A, Ma R, Zhu L. Temperature elevations in implanted prostatic tumors in mice during magnetic nanoparticle hyperthermia: in vivo experimental study. In ASME 2011 Summer Bioengineering Conference, SBC 2011. PARTS A AND B ed. 2011. p. 439-440. (ASME 2011 Summer Bioengineering Conference, SBC 2011; PARTS A AND B). https://doi.org/10.1115/SBC2011-53128