@article{b2de1ec2c99f4056afd6eeea2c51c5f6,
title = "Temporal sequences of brain activity at rest are constrained by white matter structure and modulated by cognitive demands",
abstract = "A diverse set of white matter connections supports seamless transitions between cognitive states. However, it remains unclear how these connections guide the temporal progression of large-scale brain activity patterns in different cognitive states. Here, we analyze the brain{\textquoteright}s trajectories across a set of single time point activity patterns from functional magnetic resonance imaging data acquired during the resting state and an n-back working memory task. We find that specific temporal sequences of brain activity are modulated by cognitive load, associated with age, and related to task performance. Using diffusion-weighted imaging acquired from the same subjects, we apply tools from network control theory to show that linear spread of activity along white matter connections constrains the probabilities of these sequences at rest, while stimulus-driven visual inputs explain the sequences observed during the n-back task. Overall, these results elucidate the structural underpinnings of cognitively and developmentally relevant spatiotemporal brain dynamics.",
author = "Cornblath, {Eli J.} and Arian Ashourvan and Kim, {Jason Z.} and Betzel, {Richard F.} and Rastko Ciric and Azeez Adebimpe and Baum, {Graham L.} and Xiaosong He and Kosha Ruparel and Moore, {Tyler M.} and Gur, {Ruben C.} and Gur, {Raquel E.} and Shinohara, {Russell T.} and Roalf, {David R.} and Satterthwaite, {Theodore D.} and Bassett, {Danielle S.}",
note = "Funding Information: D.S.B. and E.J.C. acknowledge support from the John D. and Catherine T. MacArthur Foundation, the Alfred P. Sloan Foundation, the ISI Foundation, the Paul Allen Foundation, the Army Research Laboratory (W911NF-10-2-0022), the Army Research Office (Bassett-W911NF-14-1-0679, Grafton-W911NF-16-1-0474, DCIST-W911NF-17-2-0181), the Office of Naval Research, the National Institute of Mental Health (2-R01-DC-009209-11, R01-MH112847, R01-MH107235, R21-M MH-106799), the National Institute of Child Health and Human Development (1R01HD086888-01), National Institute of Neurological Disorders and Stroke (R01 NS099348), and the National Science Foundation (BCS-1441502, BCS-1430087, NSF PHY-1554488, and BCS-1631550). T.D.S. acknowledges support from the National Institute of Mental Health (R01MH107703, R01MH113550, and RFMH116920). The content is solely the responsibility of the authors and does not necessarily represent the official views of any of the funding agencies. E.J.C. acknowledges support from the National Institutes of Mental Health (F30 MH118871-01).",
year = "2020",
month = dec,
day = "1",
doi = "10.1038/s42003-020-0961-x",
language = "English (US)",
volume = "3",
journal = "Communications Biology",
issn = "2399-3642",
publisher = "Springer Nature",
number = "1",
}