Terminal ileitis as a feature of henoch-schönlein purpura masquerading as Crohn disease in adults

Hemal N. Sampat, Brian P. McAllister, Darryl D. Gaines, Barbara Ostrov

Research output: Contribution to journalReview article

4 Scopus citations


Henoch-Schönlein purpura (HSP), more recently termed immunoglobulin A (IgA) vasculitis, is a systemic small-vessel vasculitis characterized by perivascular IgA deposition. This disease manifests clinically as palpable purpura, arthralgia, gastrointestinal symptoms, and renal dysfunction. Although ileitis can be seen in HSP, terminal ileitis is virtually pathognomonic for Crohn disease. We present a comprehensive review of the literature on this association, including 2 cases of our own, to demonstrate the importance of considering HSP in the differential diagnosis of ileitis suggestive of Crohn disease. We review the growing body of literature suggesting a pathophysiologic link between the conditions, possibly through an IgA-mediated mechanism.

Original languageEnglish (US)
Pages (from-to)82-85
Number of pages4
JournalJournal of Clinical Rheumatology
Issue number2
Publication statusPublished - Jan 1 2016


All Science Journal Classification (ASJC) codes

  • Rheumatology

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