Testicular Ischemia Due to Intravascular Large B-Cell Lymphoma: A Novel Presentation in an Immunosuppressed Individual

Paul Tranchida, Michael Bayerl, Mary Jo Voelpel, Margarita Palutke

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

A 56-year-old man presented with fever, disorientation, and testicular pain. He was receiving azathioprine immunosuppression for autoimmune hepatitis. Orchiectomy identified occlusion of spermatic cord vessels by intravascular large B-cell lymphoma (IVLBL) and ischemic changes in the testis. Tumor cells were positive for CD 10, CD 20, CD 30, and Epstein-Barr virus (EBV) latent membrane protein 1 (LMP-1) and early region RNA (EBER). He was treated with the cessation of azathioprine, chemotherapy, anti-CD 20 immunotherapy, and radiotherapy. Twenty months after diagnosis, he is alive with no evidence of lymphoma or hepatitis. This is the first report of IVLBL presenting with testicular ischemia. It highlights the importance of prompt diagnosis and intervention to achieve durable response. That this lymphoma arose in the setting of immunosuppressive therapy introduces additional complexity relating to pathogenesis, clinical behavior, and treatment.

Original languageEnglish (US)
Pages (from-to)319-324
Number of pages6
JournalInternational Journal of Surgical Pathology
Volume11
Issue number4
DOIs
StatePublished - Jan 1 2003

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

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