Testing neonate-infant membrane oxygenators with the University of Texas neonatal pulsatile cardiopulmonary bypass system in vitro

Akif Undar, Marian C. Holland, Russel V. Howelton, Cherie K. Benson, Jose R. Ybarra, O. La Wayne Miller, Mario M. Rossbach, Thomas M. Runge, Scott B. Johnson, Edward Y. Sako, John H. Calhoon

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Neurologic complications are already well documented after cardiopulmonary bypass (CPB) procedures in neonates and infants. Physiologic pulsatile flow CPB systems may be the alternative to the currently used steady-flow CPB circuits. In addition to the pulsatile pump, a membrane oxygenator should be chosen carefully because only a few membrane oxygenators are suitable for physiologic pulsatile flow. We have tested four different types of neonate-infant membrane oxygenators for physiologic pulsatility with The University of Texas neonate-infant pulsatile CPB system in vitro. Evaluation criteria were based on mean ejection time, extracorporeal circuit (ECC) pressure, and upstroke of dp/dt. The results suggested that the Capiox 308 hollow-fibre membrane oxygenator produced the best physiologic pulsatile waveform according to the ejection time, ECC pressure, and the upstroke of dp/dt. The Minimax Plus and Masterflo Infant hollow-fibre membrane oxygenators also produced adequate pulsatile flow. Only the Variable Prime Cobe Membrane Lung (VPCML) Plus flat-sheet membrane oxygenator failed to reach the criteria for physiologic pulsatility. Depending on the oxygenator used, the lowest priming volume of the infant CPB circuit was 415 ml and the highest 520 ml.

Original languageEnglish (US)
Pages (from-to)346-352
Number of pages7
JournalPerfusion
Volume13
Issue number5
DOIs
StatePublished - Jan 1 1998

Fingerprint

Oxygenators
Membrane Oxygenators
Cardiopulmonary Bypass
infant
Newborn Infant
Membranes
Pulsatile Flow
Pulsatile flow
Testing
Networks (circuits)
Pressure
Fibers
Nervous System
Steady flow
In Vitro Techniques
Lung
Pumps
evaluation

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Safety Research
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Undar, A., Holland, M. C., Howelton, R. V., Benson, C. K., Ybarra, J. R., Miller, O. L. W., ... Calhoon, J. H. (1998). Testing neonate-infant membrane oxygenators with the University of Texas neonatal pulsatile cardiopulmonary bypass system in vitro. Perfusion, 13(5), 346-352. https://doi.org/10.1177/026765919801300511
Undar, Akif ; Holland, Marian C. ; Howelton, Russel V. ; Benson, Cherie K. ; Ybarra, Jose R. ; Miller, O. La Wayne ; Rossbach, Mario M. ; Runge, Thomas M. ; Johnson, Scott B. ; Sako, Edward Y. ; Calhoon, John H. / Testing neonate-infant membrane oxygenators with the University of Texas neonatal pulsatile cardiopulmonary bypass system in vitro. In: Perfusion. 1998 ; Vol. 13, No. 5. pp. 346-352.
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Undar, A, Holland, MC, Howelton, RV, Benson, CK, Ybarra, JR, Miller, OLW, Rossbach, MM, Runge, TM, Johnson, SB, Sako, EY & Calhoon, JH 1998, 'Testing neonate-infant membrane oxygenators with the University of Texas neonatal pulsatile cardiopulmonary bypass system in vitro', Perfusion, vol. 13, no. 5, pp. 346-352. https://doi.org/10.1177/026765919801300511

Testing neonate-infant membrane oxygenators with the University of Texas neonatal pulsatile cardiopulmonary bypass system in vitro. / Undar, Akif; Holland, Marian C.; Howelton, Russel V.; Benson, Cherie K.; Ybarra, Jose R.; Miller, O. La Wayne; Rossbach, Mario M.; Runge, Thomas M.; Johnson, Scott B.; Sako, Edward Y.; Calhoon, John H.

In: Perfusion, Vol. 13, No. 5, 01.01.1998, p. 346-352.

Research output: Contribution to journalArticle

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AU - Undar, Akif

AU - Holland, Marian C.

AU - Howelton, Russel V.

AU - Benson, Cherie K.

AU - Ybarra, Jose R.

AU - Miller, O. La Wayne

AU - Rossbach, Mario M.

AU - Runge, Thomas M.

AU - Johnson, Scott B.

AU - Sako, Edward Y.

AU - Calhoon, John H.

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Y1 - 1998/1/1

N2 - Neurologic complications are already well documented after cardiopulmonary bypass (CPB) procedures in neonates and infants. Physiologic pulsatile flow CPB systems may be the alternative to the currently used steady-flow CPB circuits. In addition to the pulsatile pump, a membrane oxygenator should be chosen carefully because only a few membrane oxygenators are suitable for physiologic pulsatile flow. We have tested four different types of neonate-infant membrane oxygenators for physiologic pulsatility with The University of Texas neonate-infant pulsatile CPB system in vitro. Evaluation criteria were based on mean ejection time, extracorporeal circuit (ECC) pressure, and upstroke of dp/dt. The results suggested that the Capiox 308 hollow-fibre membrane oxygenator produced the best physiologic pulsatile waveform according to the ejection time, ECC pressure, and the upstroke of dp/dt. The Minimax Plus and Masterflo Infant hollow-fibre membrane oxygenators also produced adequate pulsatile flow. Only the Variable Prime Cobe Membrane Lung (VPCML) Plus flat-sheet membrane oxygenator failed to reach the criteria for physiologic pulsatility. Depending on the oxygenator used, the lowest priming volume of the infant CPB circuit was 415 ml and the highest 520 ml.

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