Testing of a 50 cc stroke volume completely implantable artificial heart: Expanding chronic mechanical circulatory support to women, adolescents, and small stature men

Sanjay M. Mehta, William Weiss, Alan J. Snyder, George A. Prophet, Walter Pae, Gerson Rosenberg, William S. Pierce

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The development of a completely implanted total artificial heart at our institution has progressed to successful in vivo and in vitro testing of a device that is nearing clinical testing. This system consists of a 70 cc stroke volume pump originally designed to be used in men of average stature. Implantation of this system remains limited by patient size; hence, many women and adolescent patients will likely be precluded from support because of their smaller stature. A system similar in design, but with a 50 cc stroke volume pump has been developed. The first in vivo study of this device has been undertaken. A calf was supported for 33 days. The animal was extubated and ambulatory within the first 6 hours of implantation, and remained healthy until the thirty-third postoperative day when it suffered an embolic neurologic event. The pump and operating system worked flawlessly throughout the period of support. Further in vivo and in vitro testing will be undertaken. Development of a scaled down total artificial heart system expands this type of circulatory support to those critically ill patients previously deemed poor candidates because of their smaller body habitus.

Original languageEnglish (US)
Pages (from-to)779-782
Number of pages4
JournalASAIO Journal
Volume46
Issue number6
DOIs
StatePublished - Jan 1 2000

Fingerprint

Artificial heart
Artificial Heart
Stroke Volume
Pumps
Testing
Equipment and Supplies
Cardiovascular System
Critical Illness
Nervous System
Animals
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

@article{d4996b2850404ac5a819ac478f85dde5,
title = "Testing of a 50 cc stroke volume completely implantable artificial heart: Expanding chronic mechanical circulatory support to women, adolescents, and small stature men",
abstract = "The development of a completely implanted total artificial heart at our institution has progressed to successful in vivo and in vitro testing of a device that is nearing clinical testing. This system consists of a 70 cc stroke volume pump originally designed to be used in men of average stature. Implantation of this system remains limited by patient size; hence, many women and adolescent patients will likely be precluded from support because of their smaller stature. A system similar in design, but with a 50 cc stroke volume pump has been developed. The first in vivo study of this device has been undertaken. A calf was supported for 33 days. The animal was extubated and ambulatory within the first 6 hours of implantation, and remained healthy until the thirty-third postoperative day when it suffered an embolic neurologic event. The pump and operating system worked flawlessly throughout the period of support. Further in vivo and in vitro testing will be undertaken. Development of a scaled down total artificial heart system expands this type of circulatory support to those critically ill patients previously deemed poor candidates because of their smaller body habitus.",
author = "Mehta, {Sanjay M.} and William Weiss and Snyder, {Alan J.} and Prophet, {George A.} and Walter Pae and Gerson Rosenberg and Pierce, {William S.}",
year = "2000",
month = "1",
day = "1",
doi = "10.1097/00002480-200011000-00024",
language = "English (US)",
volume = "46",
pages = "779--782",
journal = "ASAIO Journal",
issn = "1058-2916",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

Testing of a 50 cc stroke volume completely implantable artificial heart : Expanding chronic mechanical circulatory support to women, adolescents, and small stature men. / Mehta, Sanjay M.; Weiss, William; Snyder, Alan J.; Prophet, George A.; Pae, Walter; Rosenberg, Gerson; Pierce, William S.

In: ASAIO Journal, Vol. 46, No. 6, 01.01.2000, p. 779-782.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Testing of a 50 cc stroke volume completely implantable artificial heart

T2 - Expanding chronic mechanical circulatory support to women, adolescents, and small stature men

AU - Mehta, Sanjay M.

AU - Weiss, William

AU - Snyder, Alan J.

AU - Prophet, George A.

AU - Pae, Walter

AU - Rosenberg, Gerson

AU - Pierce, William S.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - The development of a completely implanted total artificial heart at our institution has progressed to successful in vivo and in vitro testing of a device that is nearing clinical testing. This system consists of a 70 cc stroke volume pump originally designed to be used in men of average stature. Implantation of this system remains limited by patient size; hence, many women and adolescent patients will likely be precluded from support because of their smaller stature. A system similar in design, but with a 50 cc stroke volume pump has been developed. The first in vivo study of this device has been undertaken. A calf was supported for 33 days. The animal was extubated and ambulatory within the first 6 hours of implantation, and remained healthy until the thirty-third postoperative day when it suffered an embolic neurologic event. The pump and operating system worked flawlessly throughout the period of support. Further in vivo and in vitro testing will be undertaken. Development of a scaled down total artificial heart system expands this type of circulatory support to those critically ill patients previously deemed poor candidates because of their smaller body habitus.

AB - The development of a completely implanted total artificial heart at our institution has progressed to successful in vivo and in vitro testing of a device that is nearing clinical testing. This system consists of a 70 cc stroke volume pump originally designed to be used in men of average stature. Implantation of this system remains limited by patient size; hence, many women and adolescent patients will likely be precluded from support because of their smaller stature. A system similar in design, but with a 50 cc stroke volume pump has been developed. The first in vivo study of this device has been undertaken. A calf was supported for 33 days. The animal was extubated and ambulatory within the first 6 hours of implantation, and remained healthy until the thirty-third postoperative day when it suffered an embolic neurologic event. The pump and operating system worked flawlessly throughout the period of support. Further in vivo and in vitro testing will be undertaken. Development of a scaled down total artificial heart system expands this type of circulatory support to those critically ill patients previously deemed poor candidates because of their smaller body habitus.

UR - http://www.scopus.com/inward/record.url?scp=0034327555&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034327555&partnerID=8YFLogxK

U2 - 10.1097/00002480-200011000-00024

DO - 10.1097/00002480-200011000-00024

M3 - Article

C2 - 11110281

AN - SCOPUS:0034327555

VL - 46

SP - 779

EP - 782

JO - ASAIO Journal

JF - ASAIO Journal

SN - 1058-2916

IS - 6

ER -