Testing of a 50 cc stroke volume completely implantable artificial heart: Expanding chronic mechanical circulatory support to women, adolescents, and small stature men

Sanjay M. Mehta, William J. Weiss, Alan J. Snyder, George A. Prophet, Walter E. Pae, Gerson Rosenberg, William S. Pierce

Research output: Contribution to journalArticle

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The development of a completely implanted total artificial heart at our institution has progressed to successful in vivo and in vitro testing of a device that is nearing clinical testing. This system consists of a 70 cc stroke volume pump originally designed to be used in men of average stature. Implantation of this system remains limited by patient size; hence, many women and adolescent patients will likely be precluded from support because of their smaller stature. A system similar in design, but with a 50 cc stroke volume pump has been developed. The first in vivo study of this device has been undertaken. A calf was supported for 33 days. The animal was extubated and ambulatory within the first 6 hours of implantation, and remained healthy until the thirty-third postoperative day when it suffered an embolic neurologic event. The pump and operating system worked flawlessly throughout the period of support. Further in vivo and in vitro testing will be undertaken. Development of a scaled down total artificial heart system expands this type of circulatory support to those critically ill patients previously deemed poor candidates because of their smaller body habitus.

Original languageEnglish (US)
Pages (from-to)779-782
Number of pages4
JournalASAIO Journal
Issue number6
StatePublished - Jan 1 2000


All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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